Kahkeshani Niloofar, Hadjiakhoondi Abbas, Navidpour Latifeh, Akbarzadeh Tahmineh, Safavi Malihe, Karimpour-Razkenari Elahe, Khanavi Mahnaz
a Faculty of Pharmacy and Medicinal Plants Research Centre, Department of Pharmacognosy , Tehran University of Medical Sciences , Tehran , Iran.
b Faculty of Pharmacy, Department of Medicinal Chemistry , Tehran University of Medical Sciences , Tehran , Iran.
Nat Prod Res. 2018 Nov;32(22):2745-2748. doi: 10.1080/14786419.2017.1378202. Epub 2017 Oct 15.
The essential oil of Nepeta menthoides Boiss. & Bohse., from Iran, was analysed by GC/MS. Two types of multivariate analyses were done based on the chemical composition of the investigated sample in this study and 12 other samples reported in the literature to show the chemodiversity in essential oil composition. Antimicrobial, acetylcholinesterase inhibitory and cytotoxic activities of the essential oil and its major component were assessed. Twenty-one compounds were identified, representing 96.81% of the total oil and the major constituent was 1,8-cineole (70.06%). Multivariate analyses revealed two chemotypes, i.e. nepetalactone and 1,8-cineole. The essential oil of the sample investigated in this study which was a 1,8-cineole chemotype and 1,8-cineole showed moderate antimicrobial activity and significantly inhibited the activity of acetylcholinesterase enzyme. Cytotoxicity evaluation against three breast cancer cell lines showed a potent inhibitory activity. Further investigations are necessary to confirm the variety in several populations of N. menthoides.
对来自伊朗的薄荷状荆芥（Nepeta menthoides Boiss. & Bohse.）的精油进行了气相色谱/质谱分析。基于本研究中所调查样品以及文献报道的其他12个样品的化学成分，进行了两种类型的多变量分析，以展示精油成分的化学多样性。评估了该精油及其主要成分的抗菌、乙酰胆碱酯酶抑制和细胞毒性活性。鉴定出21种化合物，占总油的96.81%，主要成分是1,8-桉叶素（70.06%）。多变量分析揭示了两种化学型，即荆芥内酯和1,8-桉叶素。本研究中所调查样品的精油属于1,8-桉叶素化学型，1,8-桉叶素显示出中等抗菌活性，并显著抑制乙酰胆碱酯酶的活性。对三种乳腺癌细胞系的细胞毒性评估显示出强效抑制活性。有必要进一步研究以确认薄荷状荆芥多个种群中的差异。
