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槲寄生:基于其植物化学、药理学和传统用途的综述。

Viscum articulatum Burm. f.: a review on its phytochemistry, pharmacology and traditional uses.

机构信息

Value Addition Research and Development-Human Health, National Innovation Foundation-India, Autonomous Body of Department of Science and Technology, Goverment of India, Gandhinagar, India.

出版信息

J Pharm Pharmacol. 2018 Feb;70(2):159-177. doi: 10.1111/jphp.12837. Epub 2017 Oct 16.

Abstract

OBJECTIVES

The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum.

METHODS

Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords.

KEY FINDINGS

Viscum articulatum has been traditionally used in different parts of the world for treatment of various ailments. Almost all the parts such as leaves, root, stem and bark are having medicinal values and are reported for their uses in Ayurvedic and Chinese system of medicine for the management of various diseases. Modern scientific studies demonstrate efficacy of this plant against hypertension, ulcer, epilepsy, inflammation, wound, nephrotoxicity, HIV, cancer, etc. Major bioactive phytochemicals include oleanolic acid, betulinic acid, eriodictyol, naringenin, β-amyrin acetate, visartisides, etc.

CONCLUSIONS

Side effects of allopathic medicines have created a global opportunity, acceptance and demand for phytomedicines. Viscum articulatum could be an excellent source of effective and safe phytomedicine for various ailments if focused translational efforts are undertaken by integrating the existing outcomes of researches.

摘要

目的

本研究旨在回顾和强调槲寄生的传统和民族植物学用途、植物化学成分、知识产权状况、生物活性和药理学活性。

方法

对槲寄生进行了全面的文献检索,并对报道的传统用途、药理学活性、存在的植物化学物质和已提交的专利进行了数据分析。使用不同的关键词在 PubMed、Science Direct、Google Scholar、Google 专利、USPTO 和 Espacenet 等科学和专利数据库中进行了搜索。

主要发现

槲寄生在世界不同地区被传统用于治疗各种疾病。几乎所有的部分,如叶子、根、茎和树皮都具有药用价值,并被报道用于治疗在印度阿育吠陀和中国医学系统中的各种疾病。现代科学研究表明,这种植物对高血压、溃疡、癫痫、炎症、伤口、肾毒性、HIV、癌症等有疗效。主要的生物活性植物化学物质包括齐墩果酸、白桦脂酸、杨梅素、柚皮苷、β-香树脂乙酸酯、visartisides 等。

结论

西药的副作用为植物药创造了全球机会、接受度和需求。如果通过整合现有的研究成果,对各种疾病进行集中的转化研究,槲寄生可能成为有效和安全的植物药的极好来源。

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