基于金属交联甲基丙烯酸酯的新型黏附系统。
New adhesive system based in metals cross-linking methacrylate.
机构信息
Post-Graduate Program in Dentistry, Department of Restorative Dentistry, Dental School, Federal University of Pelotas, Pelotas, RS, Brazil.
Post-Graduate Program in Biochemistry and Bioprospection, Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Pelotas, RS, Brazil.
出版信息
J Mech Behav Biomed Mater. 2018 Jan;77:519-526. doi: 10.1016/j.jmbbm.2017.10.010. Epub 2017 Oct 10.
This study evaluated the anti-antibiofilm potential of silver methacrylate (Ag) or di-n-butyldimethacrylatetin (Sn) in experimental adhesive systems. Ag and Sn methacrylates were incorporated at 0.5mol%, 1mol% and 2mol% in an adhesive resin. The anti-antibiofilm potential, degree of conversion (DC), microtensile bond strength (μTBS), water sorption/solubility (W), bonded interfaces pattern (SEM), cytotoxicity and leaching of Ag and Sn ions were evaluated. Data were statistically analyzed considering α = 0.05. Only Ag at 2% affected DC and μTBS. Ag at 1% and 2% and Sn at 1% and 2% showed anti-biofilm potential against Mutans streptococci. Ag at 1% and 2% and Sn at 2% showed a statistically significant difference to the control in W (p < 0.05). The additions of metal methacrylate did not affect cell viability, being the adhesive resins statistically similar to controls. Leached metals of Ag were more than 100x higher than for Sn. Between the concentration tested, Ag and Sn methacrylate at 1% presented an anti-biofilm effect without altering the mechanical properties evaluated.
本研究评估了银甲基丙烯酸酯（Ag）或二丁基二甲基锡甲基丙烯酸酯（Sn）在实验性黏接系统中的抗生物膜潜力。Ag 和 Sn 甲基丙烯酸酯以 0.5mol%、1mol%和 2mol%的浓度掺入黏接树脂中。评估了抗生物膜潜力、转化率（DC）、微拉伸黏结强度（μTBS）、吸水率/溶解度（W）、黏接界面形态（SEM）、细胞毒性和 Ag 和 Sn 离子的浸出。考虑到 α = 0.05，对数据进行了统计分析。只有 2%的 Ag 影响了 DC 和 μTBS。1%和 2%的 Ag 以及 1%和 2%的 Sn 对变形链球菌具有抗生物膜潜力。1%和 2%的 Ag 以及 2%的 Sn 在 W 方面与对照组有统计学差异（p < 0.05）。金属甲基丙烯酸酯的添加不影响细胞活力，黏接树脂与对照组在统计学上相似。Ag 浸出的金属含量是 Sn 的 100 多倍。在测试的浓度中，1%的 Ag 和 Sn 甲基丙烯酸酯具有抗生物膜作用，而不会改变评估的机械性能。
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