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2
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Biomedica. 2015 Oct 23;36(0):25-34. doi: 10.7705/biomedica.v36i0.2990.
3
Perinatally Acquired Chikungunya Infection: The Puerto Rico Experience.围产期获得性基孔肯雅热感染:波多黎各的经验
Pediatr Infect Dis J. 2016 Oct;35(10):1163. doi: 10.1097/INF.0000000000001261.
4
Congenital and perinatal complications of chikungunya fever: a Latin American experience.基孔肯雅热的先天性和围产期并发症:拉丁美洲的经验
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5
Congenital Chikungunya Virus Infection after an Outbreak in Salvador, Bahia, Brazil.巴西巴伊亚州萨尔瓦多市疫情后出现的先天性基孔肯雅病毒感染
AJP Rep. 2016 Jul;6(3):e299-300. doi: 10.1055/s-0036-1587323.
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Congenital and Neonatal Chikungunya in Colombia.哥伦比亚先天性和新生儿基孔肯雅热。
J Pediatric Infect Dis Soc. 2016 Sep;5(3):e17-20. doi: 10.1093/jpids/piw021. Epub 2016 Apr 28.
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Severe Sepsis and Septic Shock Associated with Chikungunya Virus Infection, Guadeloupe, 2014.2014年,瓜德罗普岛,基孔肯雅病毒感染相关的严重脓毒症和脓毒性休克
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Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, Colombia.基孔肯雅热后慢性炎症性风湿病:对哥伦比亚里萨拉尔达省拉比希尼亚市283例成人和儿童病例的回顾性随访研究结果
F1000Res. 2016 Mar 16;5:360. doi: 10.12688/f1000research.8235.2. eCollection 2016.
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Chikungunya virus-associated encephalitis: A cohort study on La Réunion Island, 2005-2009.基孔肯雅病毒相关脑炎:2005 - 2009年留尼汪岛队列研究
Neurology. 2016 Jan 5;86(1):94-102. doi: 10.1212/WNL.0000000000002234. Epub 2015 Nov 25.
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Post-chikungunya chronic arthralgia: Results from a retrospective follow-up study of 131 cases in Tolima, Colombia.基孔肯雅热后慢性关节痛:哥伦比亚托利马省131例病例的回顾性随访研究结果
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2015年,哥伦比亚因基孔肯雅病毒感染住院的孕妇

Pregnant Women Hospitalized with Chikungunya Virus Infection, Colombia, 2015.

作者信息

Escobar Maria, Nieto Albaro J, Loaiza-Osorio Sara, Barona Juan S, Rosso Fernando

出版信息

Emerg Infect Dis. 2017 Nov;23(11):1777-83. doi: 10.3201/eid2311.170480.

DOI:10.3201/eid2311.170480
PMID:29047427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5652420/
Abstract

In 2015 in Colombia, 60 pregnant women were hospitalized with chikungunya virus infections confirmed by reverse transcription PCR. Nine of these women required admission to the intensive care unit because of sepsis with hypoperfusion and organ dysfunction; these women met the criteria for severe acute maternal morbidity. No deaths occurred. Fifteen women delivered during acute infection; some received tocolytics to delay delivery until after the febrile episode and prevent possible vertical transmission. As recommended by a pediatric neonatologist, 12 neonates were hospitalized to rule out vertical transmission; no clinical findings suggestive of neonatal chikungunya virus infection were observed. With 36 women (60%), follow-up was performed 1 year after acute viremia; 13 patients had arthralgia in >2 joints (a relapse of infection). Despite disease severity, pregnant women with chikungunya should be treated in high-complexity obstetric units to rule out adverse outcomes. These women should also be followed up to treat potential relapses.

摘要

2015年在哥伦比亚,60名孕妇因逆转录聚合酶链反应确诊感染基孔肯雅病毒而住院。其中9名妇女因伴有低灌注和器官功能障碍的败血症而需要入住重症监护病房;这些妇女符合严重急性孕产妇发病标准。无死亡病例。15名妇女在急性感染期间分娩;一些人接受了宫缩抑制剂以延迟分娩至发热期过后,并防止可能的垂直传播。按照儿科新生儿科医生的建议,12名新生儿住院以排除垂直传播;未观察到提示新生儿基孔肯雅病毒感染的临床症状。36名妇女(60%)在急性病毒血症1年后进行了随访;13名患者有两个以上关节的关节痛(感染复发)。尽管疾病严重,但感染基孔肯雅病毒的孕妇应在高复杂性产科病房接受治疗,以排除不良后果。这些妇女还应接受随访以治疗潜在的复发。