慢性髓性白血病和急性髓性白血病患者中抗抗体的检测。
Detection of anti- antibodies in chronic myeloid leukemia and acute myeloid leukemia patients.
作者信息
Gharavi Mohammad Javad, Roozbehani Mona, Mandeh Zienat
机构信息
Department of Parasitology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Parasitology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Vet World. 2017 Sep;10(9):1063-1065. doi: 10.14202/vetworld.2017.1063-1065. Epub 2017 Sep 13.
IN
Infection of is a worldwide distribution. Toxoplasmosis in patients who are immunocompromised by virtue of underlying leukemia disease has received relatively little attention. This study was aimed to evaluate IgG and IgM antibodies of and to minimize the role of and opportunistic infection complication at the early stage of infection in leukemia patients.
MATERIALS AND METHODS
The purpose of this assay was to measure anti- IgG and IgM antibodies by enzyme-linked immunosorbent assay (ELISA) technique in leukemia patients.
RESULTS
IgG antibodies against were detected by ELISA in 96 (56.4%) leukemia patients and 72 (42.4%) control group. IgM antibodies were found in 10 patients (5.9%) with leukemia and 3 (1.8%) in the corresponding.
CONCLUSION
Our finding indicated that leukemia patients under immunosuppressive condition should not be neglected. Toxoplasmosis in leukemia patients as a main risk factor is considered, meanwhile in some patients, due to possibility of the presence of secondary infection that leads to severe toxoplasmosis.
弓形虫感染呈全球分布。因潜在白血病疾病而免疫功能低下的患者中的弓形虫病受到的关注相对较少。本研究旨在评估弓形虫的IgG和IgM抗体，并在白血病患者感染早期尽量减少弓形虫及机会性感染并发症的作用。
材料与方法
本检测的目的是通过酶联免疫吸附测定（ELISA）技术检测白血病患者抗弓形虫的IgG和IgM抗体。
结果
通过ELISA在96例（56.4%）白血病患者和72例（42.4%）对照组中检测到抗弓形虫的IgG抗体。在10例（5.9%）白血病患者中发现IgM抗体，在相应对照组中有3例（1.8%）。
结论
我们的研究结果表明，免疫抑制状态下的白血病患者不容忽视。白血病患者中的弓形虫病被视为主要危险因素，同时在一些患者中，由于可能存在继发感染，会导致严重的弓形虫病。
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