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黄连素治疗心血管疾病的研究进展

Study progress of berberine for treating cardiovascular disease.

作者信息

Xia Le-Min, Luo Mei-Hong

机构信息

Department of Hematology, Baoshan Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai 201900, China.

出版信息

Chronic Dis Transl Med. 2016 Jan 12;1(4):231-235. doi: 10.1016/j.cdtm.2015.11.006. eCollection 2015 Dec.

DOI:10.1016/j.cdtm.2015.11.006
PMID:29063012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5643735/
Abstract

Berberine (BBR) is a natural alkaloid isolated from the . While this plant has been used in Chinese medicine for more than 2500 years, interest in its effects in treating cardiovascular disease has been growing in the last decade. Recent researches showed that BBR had the effect of anti-heart failure, anti-hypertension, anti-hyperlipidemia, anti-insulin resistance, anti-arrhythmias, and anti-platelet aggregation.

摘要

黄连素（BBR）是一种从[植物名称未给出]中分离出的天然生物碱。虽然这种植物在中医中已使用了2500多年，但在过去十年中，人们对其治疗心血管疾病的作用的兴趣一直在增加。最近的研究表明，黄连素具有抗心力衰竭、抗高血压、抗高脂血症、抗胰岛素抵抗、抗心律失常和抗血小板聚集的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfcb/5643735/40d0aefccd78/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfcb/5643735/6bcec4d87dd0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfcb/5643735/40d0aefccd78/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfcb/5643735/6bcec4d87dd0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfcb/5643735/40d0aefccd78/gr2.jpg

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本文引用的文献

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Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial.胰岛素敏感性、血脂水平和肝脂肪变性指标联合营养补充剂的短期作用：一项双盲、随机、交叉临床试验。
Nutr J. 2015 Mar 28;14:30. doi: 10.1186/s12937-015-0019-y.
2
Potential benefits of berberine in the management of perimenopausal syndrome.小檗碱在围绝经期综合征管理中的潜在益处。
Oxid Med Cell Longev. 2015;2015:723093. doi: 10.1155/2015/723093. Epub 2015 Feb 17.
3
Effects of poly-bioactive compounds on lipid profile and body weight in a moderately hypercholesterolemic population with low cardiovascular disease risk: a multicenter randomized trial.
小檗碱增强 PI*Z hAAT 转基因小鼠模型的肝脏炎症和纤维化。
PLoS One. 2024 Sep 19;19(9):e0310524. doi: 10.1371/journal.pone.0310524. eCollection 2024.
4
Plant antibacterials: The challenges and opportunities.植物抗菌剂：挑战与机遇
Heliyon. 2024 May 11;10(10):e31145. doi: 10.1016/j.heliyon.2024.e31145. eCollection 2024 May 30.
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Targeting lipid reprogramming in the tumor microenvironment by traditional Chinese medicines as a potential cancer treatment.以中药靶向肿瘤微环境中的脂质重编程作为一种潜在的癌症治疗方法。
Heliyon. 2024 May 7;10(9):e30807. doi: 10.1016/j.heliyon.2024.e30807. eCollection 2024 May 15.
6
13-Butoxyberberine Bromide Inhibits Migration and Invasion in Skin Cancer A431 Cells.13-正丁氧基小檗碱溴化物抑制皮肤癌细胞 A431 的迁移和侵袭。
Molecules. 2023 Jan 19;28(3):991. doi: 10.3390/molecules28030991.
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Berberine protects cardiac cells against ferroptosis.小檗碱保护心脏细胞免受铁死亡。
Tzu Chi Med J. 2022 Mar 4;34(3):310-317. doi: 10.4103/tcmj.tcmj_236_21. eCollection 2022 Jul-Sep.
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Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends.阐述生物碱药物小檗碱的药理学和纳米技术方面：现状和未来趋势。
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The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet.黄连素对长期高脂饮食大鼠高同型半胱氨酸血症和高脂血症的影响。
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Chin Med J (Engl). 2008 Nov 5;121(21):2124-8.
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