Gao Hong, Liu Dong-E, Li Yumei, Tang Jing, Hu Shimin, Wu Xinrui, Tian Zhengwen, Tan Hongzhuan
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha.
School of Nursing, University of South China, Hengyang.
Medicine (Baltimore). 2019 Feb;98(8):e14366. doi: 10.1097/MD.0000000000014366.
The aim of this study was to investigate the relationships between uterine size and volume and clinical pregnancy rate.This longitudinal study was conducted among patients undergoing assisted reproduction technology (ART) treatment at the Reproductive Medicine Center from January 2010 to May 2017, all of whom provided informed consent to participate in the study. The uterine size, for all patients, was measured by transvaginal ultrasonography before ovarian stimulation. Clinical pregnancy was diagnosed by ultrasound confirmation of at least an intrauterine gestational sac and fetal cardiac activity 4 weeks after embryo transfer.A total of 11,924 patients were enrolled in this study. Compared to patients with uterine lengths of 50 to 59 mm (referent), patients with uterine lengths ≥60 mm had a lower clinical pregnancy rate. Compared to patients with uterine widths of 30 to 39 mm (referent), patients with uterine widths of 40 to 49 mm and those with uterine widths of ≥50 mm had a lower clinical pregnancy rate. Compared with those with a uterine anteroposterior diameter of <30 mm (referent), patients with uterine anteroposterior diameters of ≥50 mm had a lower clinical pregnancy rate. Compared with those with a uterine volume of 30 to 49 mL (referent), patients with a uterine volume ≥70 mL had a lower clinical pregnancy rate.The patients with an optimal uterine length, width, anteroposterior diameter, and volume had a higher clinical pregnancy rate than those with suboptimal uterine measurements. Uterine sizes and volumes that were too large reduced the clinical pregnancy rate.
本研究的目的是调查子宫大小和容积与临床妊娠率之间的关系。这项纵向研究是在2010年1月至2017年5月期间在生殖医学中心接受辅助生殖技术（ART）治疗的患者中进行的，所有患者均提供了参与本研究的知情同意书。对于所有患者，在卵巢刺激前通过经阴道超声测量子宫大小。在胚胎移植后4周，通过超声确认至少有宫内妊娠囊和胎儿心脏活动来诊断临床妊娠。本研究共纳入11924例患者。与子宫长度为50至59毫米（参照组）的患者相比，子宫长度≥60毫米的患者临床妊娠率较低。与子宫宽度为30至39毫米（参照组）的患者相比，子宫宽度为40至49毫米和子宫宽度≥50毫米的患者临床妊娠率较低。与子宫前后径<30毫米（参照组）的患者相比，子宫前后径≥50毫米的患者临床妊娠率较低。与子宫容积为30至49毫升（参照组）的患者相比，子宫容积≥70毫升的患者临床妊娠率较低。子宫长度、宽度、前后径和容积处于最佳状态的患者比子宫测量值欠佳的患者临床妊娠率更高。子宫大小和容积过大可降低临床妊娠率。
