Troiano Giuseppe, Caponio Vito Carlo Alberto, Boldrup Linda, Gu Xiaolian, Muzio Lorenzo Lo, Sgaramella Nicola, Wang Lixiao, Nylander Karin
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
Oncotarget. 2017 Aug 21;8(42):73029-73036. doi: 10.18632/oncotarget.20373. eCollection 2017 Sep 22.
Long noncoding RNAs (lncRNAs) are often dysregulated in cancer tissue and seem to play an important role in neoplastic processes. Recent studies have shown that the HOX transcript antisense intergenic RNA (HOTAIR) may play a role as a marker of prognosis in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to perform a meta-analysis of studies focused on the prognostic role of HOTAIR in SCCHN.
At the end of the selection process, four studies were considered eligible for inclusion in the meta-analysis, comprising a total of 271 patients. Meta-analysis revealed that high expression of HOTAIR was associated with poor overall survival (HR, 1.90; 95% CI: [1.42, 2.53]; < 0,0001), advanced tumor stage (OR, 3.44; 95% CI: [1.84, 6.43]; < 0,001) and lymph-node metastasis (OR, 3.31; 95% CI: [1.24, 8.79]; = 0,02).
The literature search was performed in the following databases: PUBMED, SCOPUS, EMBASE and Web of Science, in order to find studies that met the inclusion criteria.
Findings from this systematic review and meta-analysis revealed that HOTAIR represents a potential biomarker of prognosis in patients with squamous cell carcinoma of the head and neck.
长链非编码RNA（lncRNAs）在癌组织中常表达失调，似乎在肿瘤发生过程中起重要作用。最近的研究表明，HOX转录本反义基因间RNA（HOTAIR）可能作为头颈部鳞状细胞癌（SCCHN）的预后标志物发挥作用。本研究的目的是对聚焦于HOTAIR在SCCHN中预后作用的研究进行荟萃分析。
在筛选过程结束时，四项研究被认为符合纳入荟萃分析的条件，共包括271例患者。荟萃分析显示，HOTAIR高表达与总生存期差（HR，1.90；95%CI：[1.42，2.53]；P<0.0001）、肿瘤晚期（OR，3.44；95%CI：[1.84，6.43]；P<0.001）和淋巴结转移（OR，3.31；95%CI：[1.24，8.79]；P=0.02）相关。
在以下数据库中进行文献检索：PUBMED、SCOPUS、EMBASE和科学网，以查找符合纳入标准的研究。
该系统评价和荟萃分析的结果显示，HOTAIR是头颈部鳞状细胞癌患者预后的潜在生物标志物。
