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Toward Personalized Network Biomarkers in Alzheimer's Disease: Computing Individualized Genomic and Protein Crosstalk Maps.

作者信息

Padmanabhan Kanchana, Shpanskaya Katie, Bello Gonzalo, Doraiswamy P Murali, Samatova Nagiza F

机构信息

Department of Computer Science, North Carolina State University, Raleigh, NC, United States.

Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.

出版信息

Front Aging Neurosci. 2017 Sep 26;9:315. doi: 10.3389/fnagi.2017.00315. eCollection 2017.

DOI:10.3389/fnagi.2017.00315
PMID:29085293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5649142/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8557/5649142/7410ceb803b5/fnagi-09-00315-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8557/5649142/7410ceb803b5/fnagi-09-00315-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8557/5649142/7410ceb803b5/fnagi-09-00315-g0001.jpg

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本文引用的文献

1
Analyzing the genes related to Alzheimer's disease via a network and pathway-based approach.通过基于网络和通路的方法分析与阿尔茨海默病相关的基因。
Alzheimers Res Ther. 2017 Apr 27;9(1):29. doi: 10.1186/s13195-017-0252-z.
2
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease.GPCR 调节阿尔茨海默病中 MAPK 和 mTOR 通路的潜力。
Prog Neurobiol. 2017 Feb-Mar;149-150:21-38. doi: 10.1016/j.pneurobio.2017.01.004. Epub 2017 Feb 9.
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A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer's disease.
阿尔茨海默病的精准药理学。
Pharmacol Res. 2018 Apr;130:331-365. doi: 10.1016/j.phrs.2018.02.014. Epub 2018 Feb 16.
一种基于磁共振成像（MRI）和蛋白质组学的半机制方法，用于预测轻度认知障碍向阿尔茨海默病的转化。
Sci Rep. 2016 Jun 7;6:26712. doi: 10.1038/srep26712.
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Xtalk: a path-based approach for identifying crosstalk between signaling pathways.Xtalk：一种基于路径的信号通路间串扰识别方法。
Bioinformatics. 2016 Jan 15;32(2):242-51. doi: 10.1093/bioinformatics/btv549. Epub 2015 Sep 23.
5
Pathway mapping and development of disease-specific biomarkers: protein-based network biomarkers.疾病特异性生物标志物的通路映射与开发：基于蛋白质的网络生物标志物
J Cell Mol Med. 2015 Feb;19(2):297-314. doi: 10.1111/jcmm.12447. Epub 2015 Jan 5.
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Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack.神经影像数据中的复杂生物标志物发现：大海捞针。
Neuroimage Clin. 2013 Aug 7;3:123-31. doi: 10.1016/j.nicl.2013.07.004.
7
Inferring pathway crosstalk networks using gene set co-expression signatures.利用基因集共表达特征推断信号通路串扰网络。
Mol Biosyst. 2013 Jul;9(7):1822-8. doi: 10.1039/c3mb25506a. Epub 2013 Apr 17.
8
Discovering pathway cross-talks based on functional relations between pathways.基于通路间的功能关系发现通路串扰。
BMC Genomics. 2012;13 Suppl 7(Suppl 7):S25. doi: 10.1186/1471-2164-13-S7-S25. Epub 2012 Dec 13.
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The identification of dysfunctional crosstalk of pathways in Parkinson disease.帕金森病中通路功能失调串扰的鉴定。
Gene. 2013 Feb 15;515(1):159-62. doi: 10.1016/j.gene.2012.11.003. Epub 2012 Nov 21.
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Crosstalk in NF-κB signaling pathways.NF-κB 信号通路中的串扰。
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