Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, United States.
CSIRO Manufacturing, Clayton, Victoria 3168, Australia.
Biosens Bioelectron. 2018 Mar 15;101:227-234. doi: 10.1016/j.bios.2017.10.044. Epub 2017 Oct 20.
Flexible epidermal tattoo and textile-based electrochemical biosensors have been developed for vapor-phase detection of organophosphorus (OP) nerve agents. These new wearable sensors, based on stretchable organophosphorus hydrolase (OPH) enzyme electrodes, are coupled with a fully integrated conformal flexible electronic interface that offers rapid and selective square-wave voltammetric detection of OP vapor threats and wireless data transmission to a mobile device. The epidermal tattoo and textile sensors display a good reproducibility (with RSD of 2.5% and 4.2%, respectively), along with good discrimination against potential interferences and linearity over the 90-300mg/L range, with a sensitivity of 10.7µA∙cm∙mg (R = 0.983) and detection limit of 12mg/L in terms of OP air density. Stress-enduring inks, used for printing the electrode transducers, ensure resilience against mechanical deformations associated with textile and skin-based on-body sensing operations. Theoretical simulations are used to estimate the OP air density over the sensor surface. These fully integrated wearable wireless tattoo and textile-based nerve-agent vapor biosensor systems offer considerable promise for rapid warning regarding personal exposure to OP nerve-agent vapors in variety of decentralized security applications.
已经开发出了用于气相检测有机磷（OP）神经毒剂的柔性表皮纹身和基于纺织品的电化学生物传感器。这些基于可拉伸有机磷水解酶（OPH）酶电极的新型可穿戴传感器与完全集成的顺应性柔性电子接口相结合，可实现对 OP 蒸气威胁的快速和选择性方波伏安检测，并将无线数据传输到移动设备。表皮纹身和纺织品传感器具有良好的重现性（分别为 2.5%和 4.2%），对潜在干扰具有良好的辨别能力，在线性范围内为 90-300mg/L，灵敏度为 10.7µA·cm·mg（R = 0.983），检测限为 12mg/L（按 OP 空气密度计）。用于打印电极传感器的耐应力油墨确保了与纺织品和基于皮肤的体内传感操作相关的机械变形的弹性。理论模拟用于估计传感器表面上的 OP 空气密度。这些完全集成的可穿戴无线纹身和基于纺织品的神经毒剂蒸气生物传感器系统为快速预警提供了很大的希望，可在各种分散的安全应用中对个人接触 OP 神经毒剂蒸气进行预警。
