滑膜积液中转化生长因子β活性的活性形式和潜伏形式。
Active and latent forms of transforming growth factor beta activity in synovial effusions.
作者信息
Fava R, Olsen N, Keski-Oja J, Moses H, Pincus T
机构信息
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
出版信息
J Exp Med. 1989 Jan 1;169(1):291-6. doi: 10.1084/jem.169.1.291.
Abstract
We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta-like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.
摘要
我们通过检测16份无细胞滑膜液中活性和“潜伏”形式的转化生长因子-β（TGF-β），评估了其在类风湿性关节炎中的可能作用。根据以下四个标准，已获得滑膜积液中存在TGF-β样活性的证据：（a）TGF-β受体竞争；（b）AKR-2B和NRK-49F指示细胞在软琼脂中的集落形成；（c）生物活性的免疫中和；（d）潜伏形式的生化激活。
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