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滑膜积液中转化生长因子β活性的活性形式和潜伏形式。

Active and latent forms of transforming growth factor beta activity in synovial effusions.

作者信息

Fava R, Olsen N, Keski-Oja J, Moses H, Pincus T

机构信息

Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

出版信息

J Exp Med. 1989 Jan 1;169(1):291-6. doi: 10.1084/jem.169.1.291.

DOI:10.1084/jem.169.1.291
PMID:2909658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189180/
Abstract

We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta-like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.

摘要

我们通过检测16份无细胞滑膜液中活性和“潜伏”形式的转化生长因子-β（TGF-β），评估了其在类风湿性关节炎中的可能作用。根据以下四个标准，已获得滑膜积液中存在TGF-β样活性的证据：（a）TGF-β受体竞争；（b）AKR-2B和NRK-49F指示细胞在软琼脂中的集落形成；（c）生物活性的免疫中和；（d）潜伏形式的生化激活。

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本文引用的文献

1
Serum contains a platelet-derived transforming growth factor.血清中含有一种血小板衍生的转化生长因子。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5312-6. doi: 10.1073/pnas.79.17.5312.
2
Characterization of synovial fluid fibronectin from patients with rheumatic inflammatory diseases and healthy subjects.风湿性炎症疾病患者和健康受试者滑液纤连蛋白的特征分析。
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Transforming growth factors and control of neoplastic cell growth.转化生长因子与肿瘤细胞生长的调控
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Fibronectin-associated transforming growth factor.纤连蛋白相关转化生长因子
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Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.转化生长因子β对人成纤维细胞趋化性迁移的刺激作用。
J Exp Med. 1987 Jan 1;165(1):251-6. doi: 10.1084/jem.165.1.251.
6
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.转化生长因子-β刺激纤连蛋白和胶原蛋白的表达，并促使它们整合到细胞外基质中。
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7
Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans.转化生长因子β调节细胞外基质软骨素/硫酸皮肤素蛋白聚糖的表达和结构。
J Biol Chem. 1988 Feb 25;263(6):3039-45.
8
Some recent advances in the chemistry and biology of transforming growth factor-beta.转化生长因子-β化学与生物学领域的一些最新进展。
J Cell Biol. 1987 Sep;105(3):1039-45. doi: 10.1083/jcb.105.3.1039.
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Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.转化生长因子-β是一种有效的免疫抑制剂，可抑制白细胞介素-1依赖的淋巴细胞增殖。
J Immunol. 1988 May 1;140(9):3026-32.
10
Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells.转化生长因子-β对1型纤溶酶原激活物抑制剂、纤连蛋白和I型前胶原mRNA的调控。肺成纤维细胞和癌细胞中的不同反应。
J Biol Chem. 1988 Mar 5;263(7):3111-5.