关节炎中前列腺素的产生
Prostaglandin production in arthritis.
作者信息
Sturge R A, Yates D B, Gordon D, Franco M, Paul W, Bray A, Morley J
出版信息
Ann Rheum Dis. 1978 Aug;37(4):315-20. doi: 10.1136/ard.37.4.315.
Abstract
Inflammatory cell populations from synovial effusions or synovial villi in rheumatoid arthritis have been cultured in vitro. Prostaglandin productive capacity, measured by radioimmunoassay, showed the polymorphonuclear leucocyte rich populations from synovial effusions to be poor sources of PGE production whereas the synovial fragments produced substantial amounts of PGE activity. It is suggested that the macrophage is the major source of local prostaglandin formation both in gout and rheumatoid arthritis.
摘要
类风湿性关节炎患者滑膜积液或滑膜绒毛中的炎性细胞群体已在体外培养。通过放射免疫测定法测量的前列腺素生成能力表明，滑膜积液中富含多形核白细胞的群体是前列腺素E生成的不良来源，而滑膜碎片则产生大量的前列腺素E活性。有人认为，巨噬细胞是痛风和类风湿性关节炎中局部前列腺素形成的主要来源。
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本文引用的文献
1
1958 Revision of diagnostic criteria for rheumatoid arthritis.1958年类风湿关节炎诊断标准修订版。
Bull Rheum Dis. 1958 Dec;9(4):175-6.
2
Indomethacin and aspirin abolish prostaglandin release from the spleen.吲哚美辛和阿司匹林可抑制前列腺素从脾脏释放。
Nat New Biol. 1971 Jun 23;231(25):237-9. doi: 10.1038/newbio231237a0.
3
Aspirin selectively inhibits prostaglandin production in human platelets.阿司匹林可选择性抑制人体血小板中前列腺素的生成。
Nat New Biol. 1971 Jun 23;231(25):235-7. doi: 10.1038/newbio231235a0.
4
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
5
Acute gouty arthritis and response to colchicine in the virtual absence of synovial-fluid leukocytes.
N Engl J Med. 1974 Jun 13;290(24):1363-4. doi: 10.1056/NEJM197406132902406.
6
Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid.吲哚美辛在血清和滑液中的同步药代动力学。
Ann Rheum Dis. 1973 Sep;32(5):433-5. doi: 10.1136/ard.32.5.433.
7
Proceedings: Prostaglandin production by rabbit peritoneal polymorphonuclear leukocytes in vitro.论文：兔腹膜多形核白细胞体外前列腺素的产生
Br J Pharmacol. 1972 Feb;44(2):330P.
8
Antibodies to pharmacologically active molecules: specificities and some applications of antiprostaglandins.针对药理活性分子的抗体：抗前列腺素的特异性及一些应用
Pharmacol Rev. 1973 Jun;25(2):293-307.
9
Urate crystal induced inflammation in dog joints: sequence of synovial changes.尿酸盐结晶诱发犬关节炎症：滑膜变化的顺序
J Rheumatol. 1974 Mar;1(1):102-13.
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Proceedings: Role of prostaglandins in reactions of cellular immunity.会议论文：前列腺素在细胞免疫反应中的作用
Br J Pharmacol. 1974 Nov;52(3):453P.
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