Reif J, Pearce N, Kawachi I, Fraser J
Department of Environmental Health, Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO 80523.
Int J Cancer. 1989 Jan 15;43(1):49-54. doi: 10.1002/ijc.2910430112.
Several studies have suggested that forestry workers are at increased risk for certain types of cancer including soft-tissue sarcoma (STS) and non-Hodgkin's lymphoma (NHL). We now report a series of national case-control studies based on the New Zealand Cancer Registry (NZCR). These involved 19,904 male patients with cancer for the period 1980-1984 who were aged 20 years or more at the time of registration. For each cancer site, the registrations for the remaining sites formed the control group. Current or most recent occupational titles were coded. There was an increased risk for STS (OR = 3.24) in forestry workers which was confined to men under 60 years of age at registration. An elevation in risk for NHL (OR = 1.84) was due to an increase in risk for lymphosarcoma and reticulosarcoma (ICD 200) (OR = 3.18). Acute myeloid leukemia was also associated with forestry work, although the estimate of risk was imprecise (OR = 2.24). Among other cancer sites, an increase in risk of neoplasia of the upper gastro-intestinal tract (ICD 150, 151, 152) was demonstrated. Odds ratios were elevated for cancer of the esophagus (OR = 1.77), stomach (OR = 2.22), small intestine (OR = 5.22), gall-bladder (OR = 4.13) and pancreas (OR = 1.79), as well as for nasopharyngeal cancer (OR = 5.56). These increases in cancer risk were not present in sawmill workers in New Zealand during the same period. The factors responsible for the increased cancer risks in forestry workers remain unclear and require further study.
多项研究表明，林业工人患某些类型癌症的风险增加，包括软组织肉瘤（STS）和非霍奇金淋巴瘤（NHL）。我们现在报告一系列基于新西兰癌症登记处（NZCR）的全国性病例对照研究。这些研究涉及1980年至1984年期间19904名20岁及以上登记时患癌症的男性患者。对于每个癌症部位，其余部位的登记患者组成对照组。对当前或最近的职业头衔进行了编码。林业工人患STS的风险增加（OR = 3.24），且仅限于登记时年龄在60岁以下的男性。NHL风险升高（OR = 1.84）是由于淋巴肉瘤和网状细胞肉瘤（ICD 200）风险增加（OR = 3.18）。急性髓性白血病也与林业工作有关，尽管风险估计不准确（OR = 2.24）。在其他癌症部位，上消化道肿瘤（ICD 150、151、152）的风险增加得到证实。食管癌（OR = 1.77）、胃癌（OR = 2.22）、小肠癌（OR = 5.22）、胆囊癌（OR = 4.13）、胰腺癌（OR = 1.79）以及鼻咽癌（OR = 5.56）的比值比均升高。同期新西兰锯木厂工人不存在这些癌症风险增加的情况。林业工人癌症风险增加的原因尚不清楚，需要进一步研究。
