Laboratório de Materiais Dentários, Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, Brazil.
Centro Universitário do Distrito Federal (UDF), Brasília, Brazil.
J Dent. 2018 Feb;69:77-82. doi: 10.1016/j.jdent.2017.11.002. Epub 2017 Nov 7.
To evaluate the immediate enamel bond strength, in situ degree of conversion and the polymerisation rate of three experimental orthodontic adhesives containing triclosan-loaded halloysite nanotubes. The antibacterial and bioactivity properties of such experimental materials were also assessed.
Three experimental orthodontic adhesives were formulated by incorporating triclosan-loaded halloysite nanotubes (TCN-HNT) at different concentrations (5wt%, 10wt% and 20wt%) into a resin blend (Control). The maximum polymerisation rate of the tested adhesives was evaluated trough FTIR, while Raman was used to analyse the in situ degree of conversion (DC) at the bracket/enamel interface. The shear bond strength (SBS) of the enamel-bonded specimens was assessed at 24h. The antibacterial properties of the experimental materials against S. Mutans were evaluate up to 72h, while, their bioactivity was evaluated after 14days of artificial saliva (AS) storage through SEM-EDS and Raman spectromicroscopy.
Incorporation of TCN-HNT increased the polymerisation properties without interfering with the immediate bonding properties of the experimental adhesives. All experimental adhesives containing TCN-HNT inhibited bacterial growth at 24h, and induced mineral deposition after 14days of AS storage. At 72h, only the experimental system containing 20% TCN-HNT maintained such a capability.
Adhesives doped with TCN-HNT present improved polymerisation properties and suitable bonding performance. However, only the adhesives containing TCN-HNT >10% might promote long-term antibacterial activity and reliable mineral deposition.
The use of adhesives containing triclosan-loaded halloysite represents a promising "smart" approach to bond orthodontic brackets and bands; these might prevent enamel demineralisation and induce enamel remineralisation during the treatment.
评估三种含有三氯生负载海泡石纳米管的实验性正畸胶粘剂的即刻牙釉质粘结强度、原位转化率和聚合率。还评估了这些实验材料的抗菌和生物活性特性。
通过将三氯生负载海泡石纳米管（TCN-HNT）以不同浓度（5wt%、10wt%和 20wt%）掺入树脂混合物（对照）中，制备了三种实验性正畸胶粘剂。通过傅里叶变换红外光谱（FTIR）评估测试胶粘剂的最大聚合率，而拉曼则用于分析粘结剂/牙釉质界面的原位转化率（DC）。在 24 小时评估牙釉质粘结标本的剪切粘结强度（SBS）。通过在人工唾液（AS）中储存 14 天，通过 SEM-EDS 和拉曼光谱显微镜评估实验材料的抗菌性能，评估了实验材料对 S. Mutans 的抗菌性能，直到 72 小时。
TCN-HNT 的掺入提高了聚合性能，而不影响实验性胶粘剂的即时粘结性能。所有含有 TCN-HNT 的实验性胶粘剂在 24 小时内均抑制了细菌生长，并在 AS 储存 14 天后诱导了矿物质沉积。在 72 小时时，只有含有 20%TCN-HNT 的实验体系保持了这种能力。
掺杂 TCN-HNT 的胶粘剂具有改善的聚合性能和合适的粘结性能。然而，只有含有 TCN-HNT>10%的胶粘剂可能会促进长期的抗菌活性和可靠的矿物质沉积。
使用含有三氯生负载海泡石的胶粘剂代表了一种有前途的“智能”方法，可以将正畸托槽和带粘结起来；这些可能会在治疗过程中防止牙釉质脱矿，并诱导牙釉质再矿化。
