Salmerón-Valdés Elias Nahum, Cruz-Mondragón Ana Cecilia, Toral-Rizo Víctor Hugo, Jiménez-Rojas Leticia Verónica, Correa-Prado Rodrigo, Lara-Carrillo Edith, Morales-Valenzuela Adriana Alejandra, Scougall-Vilchis Rogelio José, López-Flores Alejandra Itzel, Hoz-Rodriguez Lia, Velásquez-Enríquez Ulises
Center for Research and Advanced Studies in Dentistry, Faculty of Dentistry, School of Dentistry, Autonomous University of Mexico State, Toluca 50130, Mexico.
Infectious Diseases Research Unit of the Mexico Children's Hospital Federico Gómez, Mexico City 06720, Mexico.
Nanomaterials (Basel). 2022 Aug 23;12(17):2891. doi: 10.3390/nano12172891.
Recently, several studies have introduced nanotechnology into the area of dental materials with the aim of improving their properties. The objective of this study is to determine the antibacterial and mechanical properties of type I glass ionomers reinforced with halloysite nanotubes modified with 2% chlorhexidine at concentrations of 5% and 10% relative to the total weight of the powder used to construct each sample. Regarding antibacterial effect, 200 samples were established and distributed into four experimental groups and six control groups (4 +ve and 2 -ve), with 20 samples each. The mechanical properties were evaluated in 270 samples, assessing microhardness (30 samples), compressive strength (120 samples), and setting time (120 samples). The groups were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy, and the antibacterial activity of the ionomers was evaluated on for 24 h. The control and positive control groups showed no antibacterial effect, while the experimental group with 5% concentration showed a zone of growth inhibition between 11.35 mm and 11.45 mm, and the group with 10% concentration showed a zone of growth inhibition between 12.50 mm and 13.20 mm. Statistical differences were observed between the experimental groups with 5% and 10% nanotubes. Regarding the mechanical properties, microhardness, and setting time, no statistical difference was found when compared with control groups, while compressive strength showed higher significant values, with ionomers modified with 10% concentration of nanotubes resulting in better compressive strength values. The incorporation of nanotubes at concentrations of 5% and 10% effectively inhibited the presence of , particularly when the dose-response relationship was taken into account, with the advantage of maintaining and improving their mechanical properties.
最近，几项研究已将纳米技术引入牙科材料领域，旨在改善其性能。本研究的目的是确定用2%洗必泰修饰的埃洛石纳米管增强的I型玻璃离子体在相对于用于构建每个样品的粉末总重量的5%和10%浓度下的抗菌和机械性能。关于抗菌效果，建立了200个样品并分为四个实验组和六个对照组（4个阳性和2个阴性），每组20个样品。在270个样品中评估了机械性能，评估了显微硬度（30个样品）、抗压强度（120个样品）和凝固时间（120个样品）。通过扫描电子显微镜和傅里叶变换红外光谱对各组进行表征，并在 上评估离子体的抗菌活性24小时。对照组和阳性对照组均未显示出抗菌效果，而5%浓度的实验组显示出11.35毫米至11.45毫米之间的生长抑制区，10%浓度的实验组显示出12.50毫米至13.20毫米之间的生长抑制区。在含5%和10%纳米管的实验组之间观察到统计学差异。关于机械性能、显微硬度和凝固时间，与对照组相比未发现统计学差异，而抗压强度显示出更高的显著值，并显示出10%浓度纳米管修饰的离子体具有更好的抗压强度值。以5%和10%的浓度掺入纳米管有效地抑制了 的存在，特别是考虑到剂量反应关系时，其优点是保持并改善了它们的机械性能。
