Nutrition and Dietetic Research Group, Section of Investigative Medicine, Faculty of Medicine, Hammersmith Campus, Imperial College London, UK.
Stable Isotope Biochemistry Laboratory, Scottish Universities Environmental Research Centre, University of Glasgow, Glasgow, UK.
Diabetes Obes Metab. 2018 Apr;20(4):1034-1039. doi: 10.1111/dom.13159. Epub 2017 Dec 17.
Short-chain fatty acids (SCFAs), produced from fermentation of dietary fibre by the gut microbiota, have been suggested to modulate energy metabolism. Previous work using rodent models has demonstrated that oral supplementation of the SCFA propionate raises resting energy expenditure (REE) by promoting lipid oxidation. The objective of the present study was to investigate the effects of oral sodium propionate on REE and substrate metabolism in humans. Eighteen healthy volunteers (9 women and 9 men; age 25 ± 1 years; body mass index 24.1 ± 1.2 kg/m ) completed 2 study visits following an overnight fast. Tablets containing a total of 6845 mg sodium propionate or 4164 mg sodium chloride were provided over the 180-minute study period in random order. REE and substrate oxidation were assessed by indirect calorimetry. Oral sodium propionate administration increased REE (0.045 ± 0.020 kcal/min; P = .036); this was accompanied by elevated rates of whole-body lipid oxidation (0.012 ± 0.006 g/min; P = .048) and was independent of changes in glucose and insulin concentrations. Future studies are warranted to determine whether the acute effects of oral sodium propionate on REE translate into positive improvements in long-term energy balance in humans.
短链脂肪酸（SCFAs）是肠道微生物发酵膳食纤维产生的，据推测可调节能量代谢。以前使用啮齿动物模型的研究表明，通过促进脂肪氧化，口服补充 SCFA 丙酸盐可提高静息能量消耗（REE）。本研究旨在探讨口服丙酸钠对人体 REE 和底物代谢的影响。18 名健康志愿者（9 名女性和 9 名男性；年龄 25±1 岁；体重指数 24.1±1.2 kg/m ）在禁食过夜后完成了 2 次研究访问。在 180 分钟的研究期间，以随机顺序提供了总计含有 6845 mg 丙酸钠或 4164 mg 氯化钠的片剂。通过间接热量法评估 REE 和底物氧化。口服丙酸钠给药增加了 REE（0.045±0.020 kcal/min；P=0.036）；这伴随着全身脂肪氧化率的升高（0.012±0.006 g/min；P=0.048），且与葡萄糖和胰岛素浓度的变化无关。未来的研究需要确定口服丙酸钠对 REE 的急性影响是否转化为人类长期能量平衡的积极改善。
