c-Met、CREB1和EGFR通过AKT/GSK-3β/Snail信号通路参与miR-493-5p对前列腺癌上皮-间质转化的抑制作用。

c-Met, CREB1 and EGFR are involved in miR-493-5p inhibition of EMT via AKT/GSK-3β/Snail signaling in prostate cancer.

作者信息

Wang Song, Wang Xiao, Li Jiangfeng, Meng Shuai, Liang Zhen, Xu Xin, Zhu Yi, Li Shiqi, Wu Jian, Xu Mingjie, Ji Alin, Lin Yiwei, Liu Ben, Zheng Xiangyi, Xie Bo, Xie Liping

机构信息

Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.

Department of Urology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, People's Republic of China.

出版信息

Oncotarget. 2017 Jul 19;8(47):82303-82313. doi: 10.18632/oncotarget.19398. eCollection 2017 Oct 10.

miR-493-5p downregulation has emerged as a critical player in cancer progression yet, the underlying mechanisms of miR-493-5p expression pattern and its function in prostate cancer remains to be elucidated. Here, we illustrate that miR-493-5p is frequently downregulated in prostate cancer, at least partially due to altered DNA methylation. miR-493-5p functions as a tumor suppressor in prostate cancer cells. c-Met, CREB1 and EGFR are downstream target genes of miR-493-5p. miR-493-5p inhibits EMT via AKT/GSK-3β/Snail signaling in prostate cancer. Taken together, our study identified c-Met, CREB1, EGFR and miR-493-5p establish a regulatory loop in prostate cancer, which could prove useful in the development of effective and therapies against prostate cancer.