Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan
Biochem Soc Trans. 2017 Dec 15;45(6):1323-1331. doi: 10.1042/BST20170128. Epub 2017 Nov 17.
Macroautophagy is an intracellular degradation system that involves the formation of membrane structures called autophagosomes, although the detailed process by which membrane lipids are supplied during autophagosome formation is yet to be elucidated. Macroautophagy is thought to be associated with canonical membrane trafficking, but several mechanistic details are still missing. In this review, the current understanding and potential mechanisms by which membrane trafficking participates in macroautophagy are described, with a focus on the enigma of the membrane protein Atg9, for which the proximal mechanisms determining its movement are disputable, despite its key role in autophagosome formation.
自噬是一种细胞内降解系统，涉及膜结构的形成，称为自噬体，尽管自噬体形成过程中膜脂质的供应的详细过程尚未阐明。自噬被认为与经典的膜运输有关，但仍有几个机制细节缺失。在这篇综述中，描述了膜运输参与自噬的当前理解和潜在机制，重点介绍了膜蛋白 Atg9 的谜团，尽管其在自噬体形成中起着关键作用，但决定其运动的近端机制仍存在争议。
