常压缺氧期间嗅觉敏感性降低。
Reduction of olfactory sensitivity during normobaric hypoxia.
作者信息
Huppertz Tilman, Freiherr Jessica, Olzowy Bernhard, Kisser Ulrich, Stephan Jutta, Fesl Gunther, Haegler Kathrin, Feddersen Berend, Fischer Rainald, Mees Klaus, Becker Sven
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Diagnostic and Interventional Neuroradiology, Uniklinik RWTH Aachen, Germany.
出版信息
Auris Nasus Larynx. 2018 Aug;45(4):747-752. doi: 10.1016/j.anl.2017.11.001. Epub 2017 Nov 15.
OBJECTIVE
Acute mountain sickness (AMS) is caused by a low partial pressure of oxygen and may occur above 2500m. The aim of this research was to evaluate olfactory and gustatory abilities of healthy subjects during baseline conditions and after seven hours of normobaric hypoxia.
METHODS
Sixteen healthy subjects were assessed using the Sniffin' Sticks, as well as intensity and pleasantness ratings. Gustatory function was evaluated utilizing the Taste Strips. Experiments were carried out under baseline conditions (518m altitude) followed by a second testing session after seven hours of normobaric hypoxia exposure (comparable to 4000m altitude).
RESULTS
During normobaric hypoxia olfactory sensitivity and intensity estimates were significantly reduced.
CONCLUSIONS
We conclude that normobaric hypoxia leads to a significant decrease of olfactory sensitivity and intensity ratings.
目的
急性高原病（AMS）由低氧分压引起，可能发生在海拔2500米以上。本研究的目的是评估健康受试者在基线条件下以及常压低氧7小时后的嗅觉和味觉能力。
方法
使用嗅觉棒以及强度和愉悦度评分对16名健康受试者进行评估。利用味觉试纸评估味觉功能。实验在基线条件下（海拔518米）进行，随后在常压低氧暴露7小时后（相当于海拔4000米）进行第二次测试。
结果
在常压低氧期间，嗅觉敏感性和强度估计值显著降低。
结论
我们得出结论，常压低氧会导致嗅觉敏感性和强度评分显著下降。
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