Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, 08826, Republic of Korea.
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.
Nat Commun. 2017 Nov 21;8(1):1664. doi: 10.1038/s41467-017-01824-6.
Soft bioelectronic devices provide new opportunities for next-generation implantable devices owing to their soft mechanical nature that leads to minimal tissue damages and immune responses. However, a soft form of the implantable optoelectronic device for optical sensing and retinal stimulation has not been developed yet because of the bulkiness and rigidity of conventional imaging modules and their composing materials. Here, we describe a high-density and hemispherically curved image sensor array that leverages the atomically thin MoS-graphene heterostructure and strain-releasing device designs. The hemispherically curved image sensor array exhibits infrared blindness and successfully acquires pixelated optical signals. We corroborate the validity of the proposed soft materials and ultrathin device designs through theoretical modeling and finite element analysis. Then, we propose the ultrathin hemispherically curved image sensor array as a promising imaging element in the soft retinal implant. The CurvIS array is applied as a human eye-inspired soft implantable optoelectronic device that can detect optical signals and apply programmed electrical stimulation to optic nerves with minimum mechanical side effects to the retina.
软性生物电子设备具有柔软的机械特性,可将对组织的损伤和免疫反应降至最低,为下一代植入式设备提供了新的机会。然而,由于传统成像模块及其组成材料的体积大和刚性,尚未开发出用于光学传感和视网膜刺激的软性植入式光电设备。在这里,我们描述了一种高密度和半球形弯曲的图像传感器阵列,该阵列利用了原子级薄的 MoS-石墨烯异质结构和应变释放器件设计。半球形弯曲的图像传感器阵列表现出对红外光的不敏感性,并成功获取了像素化的光学信号。我们通过理论建模和有限元分析验证了所提出的软材料和超薄器件设计的有效性。然后,我们提出了超薄半球形弯曲的图像传感器阵列,作为软视网膜植入物中很有前途的成像元件。该 CurvIS 阵列被用作受人眼启发的软性可植入光电设备,可检测光学信号,并对神经施加编程电刺激,对视网膜的机械副作用最小。