Anand Deepak, Chaudhuri Arunima
a Max-Planck-Institut für terrestrische Mikrobiologie , Marburg , Germany.
b Department of Cell Biology , Yale School of Medicine , New Haven , CT , USA.
Mol Membr Biol. 2016 Sep-Dec;33(6-8):125-137. doi: 10.1080/09687688.2017.1400602.
Outer membrane vesicles (OMVs) (∼50-250 nm in diameter) are produced by both pathogenic and nonpathogenic bacteria as a canonical end product of secretion. In this review, we focus on the OMVs produced by gram-negative bacteria. We provide an overview of the OMV structure, various factors regulating their production, and their role in modulating host immune response using a few representative examples. In light of the importance of the diverse cargoes carried by OMVs, we discuss the different modes of their entry into the host cell and advances in the high-throughput detection of these OMVs. A conspicuous application of OMVs lies in the field of vaccination; we discuss its success in immunization against human diseases such as pertussis, meningitis, shigellosis and aqua-farming endangering diseases like edwardsiellosis.
外膜囊泡（OMVs）（直径约50 - 250纳米）由致病性和非致病性细菌产生，是一种典型的分泌终产物。在本综述中，我们重点关注革兰氏阴性菌产生的OMVs。我们使用一些代表性实例，概述了OMV的结构、调节其产生的各种因素及其在调节宿主免疫反应中的作用。鉴于OMVs携带的多种货物的重要性，我们讨论了它们进入宿主细胞的不同方式以及这些OMVs高通量检测方面的进展。OMVs的一个显著应用在于疫苗接种领域；我们讨论了其在预防人类疾病如百日咳、脑膜炎、志贺氏菌病以及水产养殖中危及鱼类的疾病如爱德华氏菌病方面的免疫成功案例。
