Dikun P P, Pavlov K A, Ermilov V B, Volkov D P, Stefanenko Iu F
Vopr Onkol. 1987;33(12):61-7.
The article deals with a comparison of the results of human body nitrosating ability determination by two methods: (a) nitroso compound (NC) assay in diurnal urine after oral administration of its precursors, and (b) assay of the same in gastric juice after in vitro addition of precursors. The data for the first part of the investigation were obtained from the literature, and for the second one--from the experiments by the authors. Both studies used essentially identical groups of patients, primarily those suffering gastrointestinal pathology. Since the results matched to a considerable degree, it was inferred that (1) gastric juice is a factor of body nitrosating ability, and (2) in vitro determinations of said ability in gastric juice are fully justified. Moreover, the latter procedure is sometimes more practicable, particularly, in view of the marked relationship between nitrosating ability, and, especially, the efficacy of inhibitors of NC endogenous synthesis, on the one hand, and the individual characteristics of the body, on the other.
（a）口服前体后测定日间尿液中的亚硝基化合物（NC）；（b）体外添加前体后测定胃液中的亚硝基化合物。研究第一部分的数据来自文献，第二部分的数据来自作者的实验。两项研究使用的患者群体基本相同，主要是患有胃肠道疾病的患者。由于结果在很大程度上相符，因此推断：（1）胃液是人体亚硝化能力的一个因素；（2）体外测定胃液中的该能力是完全合理的。此外，后一种方法有时更可行，特别是考虑到亚硝化能力，尤其是NC内源性合成抑制剂的功效，一方面与人体的个体特征，另一方面之间存在明显的关系。
