Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.
Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands.
Cold Spring Harb Perspect Biol. 2017 Dec 1;9(12):a021642. doi: 10.1101/cshperspect.a021642.
SummaryType III intermediate filament (IF) proteins assemble into cytoplasmic homopolymeric and heteropolymeric filaments with other type III and some type IV IFs. These highly dynamic structures form an integral component of the cytoskeleton of muscle, brain, and mesenchymal cells. Here, we review the current ideas on the role of type III IFs in health and disease. It turns out that they not only offer resilience to mechanical strains, but, most importantly, they facilitate very efficiently the integration of cell structure and function, thus providing the necessary scaffolds for optimal cellular responses upon biochemical stresses and protecting against cell death, disease, and aging.
摘要 III 型中间丝（IF）蛋白与其他 III 型和一些 IV 型 IF 一起组装成细胞质同聚和异聚纤维。这些高度动态的结构是肌肉、大脑和间充质细胞细胞骨架的组成部分。在这里，我们回顾了 III 型 IF 在健康和疾病中的作用的现有观点。事实证明，它们不仅提供了对机械应变的弹性，而且最重要的是，它们非常有效地促进了细胞结构和功能的整合，从而为生化应激下最佳细胞反应提供了必要的支架，并防止细胞死亡、疾病和衰老。
