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轮状病毒疫苗引入前的肠套叠住院病例：来自印度泰米尔纳德邦两家转诊医院的回顾性数据。

Intussusception hospitalizations before rotavirus vaccine introduction: Retrospective data from two referral hospitals in Tamil Nadu, India.

机构信息

Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India.

ICMR - National Institute of Epidemiology, Chennai, India.

出版信息

Vaccine. 2018 Dec 14;36(51):7820-7825. doi: 10.1016/j.vaccine.2017.11.043. Epub 2017 Dec 2.

DOI:10.1016/j.vaccine.2017.11.043
PMID:29199044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6290388/
Abstract

BACKGROUND

The indigenous oral rotavirus vaccine Rotavac® was introduced into the public immunization system in India in 2016 and will be expanded in phases. This data will describe the epidemiology of intussusception in India in absence of rotavirus vaccination and will help in setting up or designing a safety monitoring system.

METHODS

Medical records of intussusception cases between 2013 and 2016 in two major referral hospitals in Tamil Nadu, India were reviewed, and data on clinical presentation and management and outcome were collated.

RESULTS

A total of 284 cases of intussusception were diagnosed and managed at the two centers of which 280/284 could be classified as level 1 by the Brighton criteria. Median age at presentation was 8 months (Inter Quartile Range, IQR 6-17.2) with a male to female ratio of 2.1:1. Over half (57.7%) required surgical intervention while the rest underwent non-surgical or conservative management.

CONCLUSIONS

Retrospective data from referral hospitals is sufficient to classify cases of intussusception by the Brighton criteria. These baseline data will be useful for monitoring when rotavirus vaccination is introduced.

摘要

背景

本土口服轮状病毒疫苗 Rotavac® 于 2016 年在印度纳入公共免疫计划，并将分阶段扩大使用。本数据将描述印度在没有轮状病毒疫苗接种情况下的肠套叠流行病学，并有助于建立或设计安全监测系统。

方法

回顾了印度泰米尔纳德邦两家主要转诊医院 2013 年至 2016 年期间肠套叠病例的医疗记录，并对临床表现、治疗和结局数据进行了整理。

结果

两家中心共诊断和管理了 284 例肠套叠，其中 280/284 例可根据布莱顿标准分类为 1 级。发病中位年龄为 8 个月（四分位间距 IQR 6-17.2），男女比例为 2.1:1。超过一半（57.7%）需要手术干预，其余则接受非手术或保守治疗。

结论

转诊医院的回顾性数据足以根据布莱顿标准对肠套叠病例进行分类。这些基线数据将有助于在引入轮状病毒疫苗时进行监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb7a/6290388/bcbb0bd73699/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb7a/6290388/021df19510c4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb7a/6290388/bcbb0bd73699/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb7a/6290388/021df19510c4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb7a/6290388/bcbb0bd73699/gr2.jpg

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