Thamboo Andrew, Mulholland Graeme, Matthews Kathleen, Ayoub Noel, Anderson Donald
Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Road, Stanford, CA 94305, USA.
World J Otorhinolaryngol Head Neck Surg. 2016 Dec 16;2(4):203-207. doi: 10.1016/j.wjorl.2016.07.003. eCollection 2016 Dec.
Honey (Manuka honey) has proven to be effective in improving acute and chronic wound healing presumably due to its antibacterial and anti-inflammatory properties. The aim is to determine if Manuka honey decreases scar formation and results in a cosmetically appealing scar.
A prospective single-blinded randomized control trial was performed. All patients received an 8 cm incision. Patients randomized to honey treatment were instructed to apply Manuka honey paste topically to the incision site once per day post surgery for 4 weeks. The patients' scar was then analyzed objectively by a blinded observer and subjectively at 4 and 8 weeks postoperatively. The primary outcome measure used was the Patient and Observer Scar Assessment Scale (POSAS).
A total of 21 patients completed the entire scar analysis (honey treatment = 9, standard treatment = 12). There was no statistically significant difference between patient scar assessment scale and observer scar assessment scale at 4 and 8 weeks postoperatively.
Despite Honey's reported anti-inflammatory and antibacterial properties, this study did not show a difference in scar appearance when applied.
麦卢卡蜂蜜已被证明能有效促进急慢性伤口愈合，这可能归因于其抗菌和抗炎特性。本研究旨在确定麦卢卡蜂蜜是否能减少瘢痕形成，并形成美观的瘢痕。
进行了一项前瞻性单盲随机对照试验。所有患者均接受8厘米的切口。随机接受蜂蜜治疗的患者被指示在术后每天在切口部位局部涂抹一次麦卢卡蜂蜜膏，持续4周。然后由一位盲法观察者对患者的瘢痕进行客观分析，并在术后4周和8周进行主观评估。使用的主要结局指标是患者与观察者瘢痕评估量表（POSAS）。
共有21名患者完成了整个瘢痕分析（蜂蜜治疗组=9名，标准治疗组=12名）。术后4周和8周，患者瘢痕评估量表与观察者瘢痕评估量表之间无统计学显著差异。
尽管麦卢卡蜂蜜具有抗炎和抗菌特性，但本研究并未显示应用蜂蜜后瘢痕外观有差异。
