• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

接触环境微生物群可解释重大洪水后持续的腹痛和肠易激综合征。

Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood.

作者信息

Yusof NurFadhilah, Hamid Nurhazwani, Ma Zheng Feei, Lawenko Rona Marie, Wan Mohammad Wan Mohd Zahiruddin, Collins Deirdre A, Liong Min Tze, Odamaki Toshitaka, Xiao Jinzhong, Lee Yeong Yeh

机构信息

School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan Malaysia.

Department of Public Health, Xi'an Jiaotong-Liverpool University, Suzhou, China.

出版信息

Gut Pathog. 2017 Dec 14;9:75. doi: 10.1186/s13099-017-0224-7. eCollection 2017.

DOI:10.1186/s13099-017-0224-7
PMID:29255490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5729606/
Abstract

BACKGROUND

After an environmental disaster, the affected community is at increased risk for persistent abdominal pain but mechanisms are unclear. Therefore, our study aimed to determine association between abdominal pain and poor water, sanitation and hygiene (WaSH) practices, and if small intestinal bacterial overgrowth (SIBO) and/or gut dysbiosis explain IBS, impaired quality of life (QOL), anxiety and/or depression after a major flood.

RESULTS

New onset abdominal pain, IBS based on the Rome III criteria, WaSH practices, QOL, anxiety and/or depression, SIBO (hydrogen breath testing) and stools for metagenomic sequencing were assessed in flood victims. Of 211 participants, 37.9% ( = 80) had abdominal pain and 17% ( = 36) with IBS subtyped diarrhea and/or mixed type ( = 27 or 12.8%) being the most common. Poor WaSH practices and impaired quality of life during flood were significantly associated with IBS. Using linear discriminant analysis effect size method, gut dysbiosis was observed in those with anxiety (Bacteroidetes and Proteobacteria, effect size 4.8), abdominal pain (Fusobacteria and , effect size 4.0) and IBS ( and , effect size 3.0).

CONCLUSION

Disturbed gut microbiota because of environmentally-derived organisms may explain persistent abdominal pain and IBS after a major environmental disaster in the presence of poor WaSH practices.

摘要

背景

在一场环境灾难之后，受灾社区持续性腹痛的风险增加，但相关机制尚不清楚。因此，我们的研究旨在确定腹痛与不良的水、环境卫生和个人卫生（WaSH）习惯之间的关联，以及小肠细菌过度生长（SIBO）和/或肠道生态失调是否能解释在一场重大洪水之后出现的肠易激综合征（IBS）、生活质量受损（QOL）、焦虑和/或抑郁。

结果

对洪水受害者评估了新发腹痛、基于罗马Ⅲ标准的IBS、WaSH习惯、生活质量、焦虑和/或抑郁、SIBO（氢呼气试验）以及用于宏基因组测序的粪便样本。在211名参与者中，37.9%（n = 80）有腹痛，17%（n = 36）患有IBS，其中以腹泻型和/或混合型（n = 27或12.8%）最为常见。洪水期间不良的WaSH习惯和生活质量受损与IBS显著相关。使用线性判别分析效应量方法，在患有焦虑症的人群中观察到肠道生态失调（拟杆菌门和变形菌门，效应量4.8）、腹痛人群（梭杆菌门等，效应量4.0）以及IBS人群（等，效应量3.0）。

结论

在存在不良WaSH习惯的情况下，环境来源微生物导致的肠道微生物群紊乱可能解释重大环境灾难后出现的持续性腹痛和IBS。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/28e109987d28/13099_2017_224_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/1b841476ffab/13099_2017_224_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/8d4bdaaf6fa3/13099_2017_224_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/640fa7be89df/13099_2017_224_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/28e109987d28/13099_2017_224_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/1b841476ffab/13099_2017_224_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/8d4bdaaf6fa3/13099_2017_224_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/640fa7be89df/13099_2017_224_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4769/5729606/28e109987d28/13099_2017_224_Fig4_HTML.jpg

相似文献

1
Exposure to environmental microbiota explains persistent abdominal pain and irritable bowel syndrome after a major flood.接触环境微生物群可解释重大洪水后持续的腹痛和肠易激综合征。
Gut Pathog. 2017 Dec 14;9:75. doi: 10.1186/s13099-017-0224-7. eCollection 2017.
2
Duodenal and rectal mucosal microbiota related to small intestinal bacterial overgrowth in diarrhea-predominant irritable bowel syndrome.腹泻型肠易激综合征中小肠细菌过度生长相关的十二指肠和直肠黏膜微生物群。
J Gastroenterol Hepatol. 2020 May;35(5):795-805. doi: 10.1111/jgh.14910. Epub 2019 Nov 5.
3
Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster.婴儿双歧杆菌 M-63 可改善洪灾后发生的肠易激综合征患者的心理健康。
Benef Microbes. 2019 Mar 13;10(2):111-120. doi: 10.3920/BM2018.0008. Epub 2018 Dec 10.
4
[Clinical features of irritable bowel syndrome with small intestinal bacterial overgrowth and a preliminary study of effectiveness of Rifaximin].小肠细菌过度生长型肠易激综合征的临床特征及利福昔明疗效的初步研究
Zhonghua Yi Xue Za Zhi. 2016 Jun 28;96(24):1896-902. doi: 10.3760/cma.j.issn.0376-2491.2016.24.005.
5
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome - An Update.小肠细菌过度生长与肠易激综合征——最新进展
Front Psychiatry. 2020 Jul 10;11:664. doi: 10.3389/fpsyt.2020.00664. eCollection 2020.
6
Small intestinal bacterial overgrowth is associated with Diarrhea-predominant irritable bowel syndrome by increasing mainly abundance.小肠细菌过度生长主要通过增加丰度与腹泻型肠易激综合征相关。
Scand J Gastroenterol. 2019 Dec;54(12):1419-1425. doi: 10.1080/00365521.2019.1694067. Epub 2019 Nov 25.
7
[The dietary features of diarrhea predominant irritable bowel syndrome patients with small intestinal bowel overgrowth].腹泻型肠易激综合征合并小肠细菌过度生长患者的饮食特点
Zhonghua Nei Ke Za Zhi. 2017 Aug 1;56(8):567-571. doi: 10.3760/cma.j.issn.0578-1426.2017.08.003.
8
Short-course Rifaximin therapy efficacy and lactulose hydrogen breath test in Chinese patients with diarrhea-predominant irritable bowel syndrome.利福昔明短程疗法疗效及乳果糖氢呼气试验在腹泻型肠易激综合征中国患者中的应用。
BMC Gastroenterol. 2020 Jun 12;20(1):187. doi: 10.1186/s12876-020-01336-6.
9
A meta-analysis on small intestinal bacterial overgrowth in patients with different subtypes of irritable bowel syndrome.一项关于不同亚型肠易激综合征患者小肠细菌过度生长的荟萃分析。
J Gastroenterol Hepatol. 2020 Jun;35(6):922-931. doi: 10.1111/jgh.14938. Epub 2019 Dec 17.
10
Double-Blind Placebo-Controlled Study of Rifaximin and Lactulose Hydrogen Breath Test in Gulf War Veterans with Irritable Bowel Syndrome.利福昔明和乳果糖氢呼气试验在海湾战争退役军人中治疗肠易激综合征的双盲安慰剂对照研究。
Dig Dis Sci. 2019 Mar;64(3):838-845. doi: 10.1007/s10620-018-5344-5. Epub 2018 Oct 28.

引用本文的文献

1
The Role of the Gut Microbiota in Health, Diet, and Disease with a Focus on Obesity.肠道微生物群在健康、饮食和疾病中的作用，重点关注肥胖问题。
Foods. 2025 Feb 4;14(3):492. doi: 10.3390/foods14030492.
2
Factors Associated With the Prevalence of Irritable Bowel Syndrome: The Miyagi Part of the Tohoku Medical Megabank Project Community-based Cohort Study.与肠易激综合征患病率相关的因素：东北医学大数据库项目宫城县社区队列研究的一部分
J Neurogastroenterol Motil. 2024 Apr 30;30(2):208-219. doi: 10.5056/jnm23090.
3
Infants exposed to Hurricane Maria have gut microbiomes with reduced diversity and altered metabolic capacity.

本文引用的文献

1
Post-Infectious Irritable Bowel Syndrome.感染后肠易激综合征
Curr Gastroenterol Rep. 2017 Sep 25;19(11):56. doi: 10.1007/s11894-017-0595-4.
2
Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study.从新生儿到百岁老人肠道微生物群组成的年龄相关变化：一项横断面研究。
BMC Microbiol. 2016 May 25;16:90. doi: 10.1186/s12866-016-0708-5.
3
Climate Change, Extreme Weather Events, and Human Health Implications in the Asia Pacific Region.亚太地区的气候变化、极端天气事件及其对人类健康的影响
暴露于飓风玛丽亚下的婴儿的肠道微生物组多样性降低，代谢能力改变。
mSphere. 2023 Oct 24;8(5):e0013423. doi: 10.1128/msphere.00134-23. Epub 2023 Sep 27.
4
Climate Change and the Esophagus: Speculations on Changing Disease Patterns as the World Warms.气候变化与食管：世界变暖之际对疾病模式变化的推测。
Curr Gastroenterol Rep. 2023 Nov;25(11):280-288. doi: 10.1007/s11894-023-00888-3. Epub 2023 Sep 1.
5
The Brain-Gut Clinic in Hospital Universiti Sains Malaysia: Pioneering New Service to Advance Neuro-Gastroenterology and Motility in Malaysia.马来西亚理科大学医院的脑肠诊所：开创推进马来西亚神经胃肠病学和胃肠动力研究的新服务。
Malays J Med Sci. 2023 Jun;30(3):1-7. doi: 10.21315/mjms2023.30.3.1. Epub 2023 Jun 27.
6
In Vitro Inhibition of Growth, Biofilm Formation, and Persisters of by Pinaverium Bromide.匹维溴铵对[具体对象]生长、生物膜形成及持留菌的体外抑制作用
ACS Omega. 2023 Mar 6;8(10):9652-9661. doi: 10.1021/acsomega.3c00340. eCollection 2023 Mar 14.
7
The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles.西班牙 COVID-19 大流行后人群的肠-微生物群-脑轴：与焦虑、创伤和抑郁特征相关的微生物组组成。
Gut Microbes. 2023 Jan-Dec;15(1):2162306. doi: 10.1080/19490976.2022.2162306.
8
Gut microbiome is associated with metabolic syndrome accompanied by elevated gamma-glutamyl transpeptidase in men.肠道微生物群与男性代谢综合征伴γ-谷氨酰转肽酶升高有关。
Front Cell Infect Microbiol. 2022 Jul 29;12:946757. doi: 10.3389/fcimb.2022.946757. eCollection 2022.
9
The Probiotic VSL#3 Does Not Seem to Be Efficacious for the Treatment of Gastrointestinal Symptomatology of Patients with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.益生菌VSL#3似乎对治疗纤维肌痛患者的胃肠道症状无效：一项随机、双盲、安慰剂对照临床试验。
Pharmaceuticals (Basel). 2021 Oct 19;14(10):1063. doi: 10.3390/ph14101063.
10
Age and Infection Impact Canine Gut Microbiota.年龄和感染影响犬类肠道微生物群。
Microorganisms. 2021 Sep 2;9(9):1862. doi: 10.3390/microorganisms9091862.
Asia Pac J Public Health. 2016 Mar;28(2 Suppl):8S-14S. doi: 10.1177/1010539515599030. Epub 2015 Sep 16.
4
Proteobacteria: microbial signature of dysbiosis in gut microbiota.变形菌门：肠道微生物失调的微生物特征。
Trends Biotechnol. 2015 Sep;33(9):496-503. doi: 10.1016/j.tibtech.2015.06.011. Epub 2015 Jul 22.
5
A cross-sectional survey on the health status and the health-related quality of life of the elderly after flood disaster in Bazhong city, Sichuan, China.中国四川省巴中市洪灾过后老年人健康状况及健康相关生活质量的横断面调查
BMC Public Health. 2015 Feb 19;15:163. doi: 10.1186/s12889-015-1402-5.
6
Fusobacterium detected in colonic biopsy and clinicopathological features of ulcerative colitis in Japan.在日本溃疡性结肠炎患者的结肠活检中检测到的梭杆菌及其临床病理特征
Dig Dis Sci. 2015 Jan;60(1):205-10. doi: 10.1007/s10620-014-3316-y. Epub 2014 Aug 8.
7
Burden of disease from inadequate water, sanitation and hygiene in low- and middle-income settings: a retrospective analysis of data from 145 countries.低收入和中等收入地区因水、环境卫生和个人卫生条件不足导致的疾病负担：对145个国家数据的回顾性分析
Trop Med Int Health. 2014 Aug;19(8):894-905. doi: 10.1111/tmi.12329. Epub 2014 Apr 30.
8
Comparison of methods for fecal microbiome biospecimen collection.粪便微生物组生物样本采集方法的比较
BMC Microbiol. 2014 Apr 23;14:103. doi: 10.1186/1471-2180-14-103.
9
Breath testing for small intestinal bacterial overgrowth: maximizing test accuracy.小肠细菌过度生长的呼吸试验：最大限度提高试验准确性。
Clin Gastroenterol Hepatol. 2014 Dec;12(12):1964-72; quiz e119-20. doi: 10.1016/j.cgh.2013.09.055. Epub 2013 Oct 1.
10
A Rome III survey of functional dyspepsia among the ethnic Malays in a primary care setting.在初级保健环境中对马来族功能性消化不良进行的罗马 III 调查。
BMC Gastroenterol. 2013 May 14;13:84. doi: 10.1186/1471-230X-13-84.