Center for Neural Science, New York University, New York, United States.
Elife. 2017 Dec 19;6:e29742. doi: 10.7554/eLife.29742.
Pyramidal cells and interneurons expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) show cell-type-specific connectivity patterns leading to a canonical microcircuit across cortex. Experiments recording from this circuit often report counterintuitive and seemingly contradictory findings. For example, the response of SST cells in mouse V1 to top-down behavioral modulation can change its sign when the visual input changes, a phenomenon that we call response reversal. We developed a theoretical framework to explain these seemingly contradictory effects as emerging phenomena in circuits with two key features: interactions between multiple neural populations and a nonlinear neuronal input-output relationship. Furthermore, we built a cortical circuit model which reproduces counterintuitive dynamics observed in mouse V1. Our analytical calculations pinpoint connection properties critical to response reversal, and predict additional novel types of complex dynamics that could be tested in future experiments.
表达钙结合蛋白 parvalbumin（PV）、somatostatin（SST）和 vasoactive intestinal peptide（VIP）的锥体神经元和中间神经元表现出特定于细胞类型的连接模式，导致整个皮层的典型微电路。从这个电路进行记录的实验经常报告违背直觉和看似矛盾的发现。例如，当视觉输入改变时，小鼠 V1 中 SST 细胞对自上而下的行为调节的反应可能会改变其符号，我们称之为反应反转。我们开发了一个理论框架来解释这些看似矛盾的效应，这些效应是具有两个关键特征的电路中出现的现象：多个神经元群体之间的相互作用和神经元输入-输出关系的非线性。此外，我们构建了一个皮质电路模型，该模型再现了在小鼠 V1 中观察到的违反直觉的动力学。我们的分析计算确定了对反应反转至关重要的连接特性，并预测了其他可能在未来实验中进行测试的新型复杂动力学。
