Vieira-Baptista Pedro, Grinceviciene Svitrigaile, Bellen Gert, Sousa Carlos, Saldanha Conceição, Broeck Davy Vanden, Bogers John-Paul, Donders Gilbert
Department of Gynecology and Obstetrics, Centro Hospitalar de São João, Porto, Portugal.
Ascendere Non-Governmental Organization, Lisbon, Portugal.
Infect Dis Obstet Gynecol. 2017;2017:3058569. doi: 10.1155/2017/3058569. Epub 2017 Nov 13.
To characterize the vaginal microbiome and the rate of sexually transmitted infections (STIs) in the women of Príncipe (São Tomé and Príncipe).
Cross-sectional study of 100 consecutive women, invited for a free appointment and cervical cancer screening. A vaginal slide (wet mount microscopy) and a cervical sample (ThinPrep®) (Pap test, high risk [HR-HPV], . [NG], . [TV], and . [CT]) were obtained.
TV, NG, CT, and HIV were found in 8.0%, 2.0%, 3.0%, and 2.0%, respectively, and were more prevalent in younger women. HR-HPV was positive in 36.7%; 2 were positive for HPV18, but none for HPV16. Coinfection of HPV with other STIs was 8.3%. Prevalence of abnormal vaginal flora (AVF) was 82.5%, mostly bacterial vaginosis (BV) 54.6%, and moderate/severe aerobic vaginitis (msAV) 25.8%. HR-HPV was not related to BV ( = 0.67). The association of abnormal Pap test with msAV was not significant ( = 0.08).
The prevalence of NG, CT, TV, and HR-HPV was according to expected, while that of HR-AVF was higher. The surprisingly low prevalence of HPV16 and HPV18 must be considered in the design of programs for prevention and vaccination; this setting can be useful as a model for postvaccination scenarios.
描述圣多美和普林西比岛普林西比地区女性的阴道微生物群及性传播感染（STIs）率。
对100名连续就诊的女性进行横断面研究，这些女性受邀免费就诊并接受宫颈癌筛查。获取阴道涂片（湿片显微镜检查）和宫颈样本（ThinPrep®）（巴氏试验、高危型[HR-HPV]、淋病奈瑟菌[NG]、滴虫[TV]和沙眼衣原体[CT]）。
分别在8.0%、2.0%、3.0%和2.0%的女性中发现滴虫、淋病奈瑟菌、沙眼衣原体和艾滋病毒，且在年轻女性中更为普遍。HR-HPV阳性率为36.7%；2人HPV18阳性，但无人HPV16阳性。HPV与其他性传播感染的合并感染率为8.3%。异常阴道菌群（AVF）的患病率为82.5%，主要是细菌性阴道病（BV）占54.6%，中度/重度需氧菌性阴道炎（msAV）占25.8%。HR-HPV与BV无关（P = 0.67）。异常巴氏试验与msAV的关联不显著（P = 0.08）。
淋病奈瑟菌、沙眼衣原体、滴虫和HR-HPV的患病率符合预期，而HR-AVF的患病率较高。在预防和疫苗接种计划的设计中必须考虑到HPV16和HPV18令人惊讶的低患病率；这种情况可作为疫苗接种后情况的模型。
