a Department of Biological Sciences , Al-Hikmah University , Ilorin , Nigeria.
b Antioxidants, Redox Biology and Toxicology Research Group, Department of Medical Biochemistry , College of Health Sciences, Nile University of Nigeria , Abuja , Nigeria.
Arch Physiol Biochem. 2018 Dec;124(5):410-417. doi: 10.1080/13813455.2017.1415938. Epub 2017 Dec 20.
This study investigated the influence of caffeic, ferulic, gallic and protocatechuic acids on high-fructose diet-induced metabolic syndrome in rats. Oral administration of the phenolic acids significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Furthermore, phenolic acids restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). Similarly, elevated tumour necrosis factor-α, interleukin-6 and -8 were significantly lowered. Administration of phenolic acids restored High-fructose diet-mediated increase in the levels of lipid parameters and indices of atherosclerosis, cardiac and cardiovascular diseases. High-fructose diet-mediated decrease in activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase) and increase in oxidative stress biomarkers (reduced glutathione, lipid peroxidation products, protein oxidation and fragmented DNA) were significantly restored by the phenolic acids. The result of this study shows protective influence of caffeic acid, ferulic acid, gallic acid and protocatechuic acid in high-fructose diet-induced metabolic syndrome.
本研究探讨了咖啡酸、阿魏酸、没食子酸和原儿茶酸对高果糖饮食诱导的大鼠代谢综合征的影响。这些酚酸的口服给药显著逆转了高果糖饮食介导的体重指数和血糖升高。此外，酚酸还恢复了高果糖饮食介导的代谢激素（胰岛素、瘦素和脂联素）的改变。同样，升高的肿瘤坏死因子-α、白细胞介素-6 和白细胞介素-8 也显著降低。酚酸的给药还恢复了高果糖饮食介导的脂质参数和动脉粥样硬化、心脏和心血管疾病指标的增加。高果糖饮食介导的抗氧化酶（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和葡萄糖 6-磷酸脱氢酶）活性降低和氧化应激生物标志物（还原型谷胱甘肽、脂质过氧化产物、蛋白质氧化和断裂的 DNA）增加，也被酚酸显著恢复。这项研究的结果表明，咖啡酸、阿魏酸、没食子酸和原儿茶酸对高果糖饮食诱导的代谢综合征具有保护作用。
