Institute of Virology, University of Bonn Medical Centre, Institute of Virology, Germany.
Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Germany.
J Infect Dis. 2017 Dec 19;216(12):1501-1504. doi: 10.1093/infdis/jix539.
Reliable diagnosis of congenital Zika virus (ZIKV) infection is challenging. Here, we assessed ZIKV-specific neutralizing antibodies in 28 mothers of children with microcephaly (cases) and 122 controls from northeastern Brazil using plaque reduction neutralization tests. ZIKV-specific antibody titers were significantly higher in cases than in controls (t test, P < .0001). We identified a putative case of congenital Zika syndrome retrospectively by unusually high ZIKV-specific antibody titers. High ZIKV-specific antibody titers in cases were unrelated to prior dengue virus infection. Our data suggest a strong immunological stimulus from prolonged placental or transplacental ZIKV shedding and potential utility of maternal antibody titers to corroborate congenital ZIKV infection.
先天性寨卡病毒（ZIKV）感染的可靠诊断具有挑战性。在这里，我们使用蚀斑减少中和试验评估了来自巴西东北部 28 名小头畸形患儿的母亲（病例）和 122 名对照的 ZIKV 特异性中和抗体。病例组的 ZIKV 特异性抗体滴度明显高于对照组（t 检验，P<0.0001）。我们通过 ZIKV 特异性抗体滴度异常升高，回顾性地确定了一例疑似先天性寨卡综合征病例。病例组中 ZIKV 特异性抗体滴度高与既往登革热病毒感染无关。我们的数据表明，胎盘或胎盘间 ZIKV 持续脱落会引起强烈的免疫刺激，并且母体抗体滴度可能有助于证实先天性 ZIKV 感染。
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