Department of Animal Resources Science, Dankook University, Cheonan 31116, Republic of Korea.
Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.
Genomics. 2019 Jan;111(1):24-33. doi: 10.1016/j.ygeno.2017.12.009. Epub 2017 Dec 23.
Lactobacillus mucosae is currently of interest as putative probiotics due to their metabolic capabilities and ability to colonize host mucosal niches. L. mucosae LM1 has been studied in its functions in cell adhesion and pathogen inhibition, etc. It demonstrated unique abilities to use energy from carbohydrate and non-carbohydrate sources. Due to these functions, we report the first complete genome sequence of an L. mucosae strain, L. mucosae LM1. Analysis of the pan-genome in comparison with closely-related Lactobacillus species identified a complete glycogen metabolism pathway, as well as folate biosynthesis, complementing previous proteomic data on the LM1 strain. It also revealed common and unique niche-adaptation genes among the various L. mucosae strains. The aim of this study was to derive genomic information that would reveal the probable mechanisms underlying the probiotic effect of L. mucosae LM1, and provide a better understanding of the nature of L. mucosae sp.
黏蛋白乳杆菌目前因其代谢能力和定植宿主黏膜生态位的能力而被认为是潜在的益生菌。黏蛋白乳杆菌 LM1 的细胞黏附和抑制病原体等功能已被研究。它表现出独特的能力，能够利用碳水化合物和非碳水化合物来源的能量。基于这些功能，我们报告了黏蛋白乳杆菌菌株 LM1 的第一个完整基因组序列。与密切相关的乳杆菌物种的泛基因组分析确定了完整的糖原代谢途径，以及叶酸生物合成，补充了先前关于 LM1 菌株的蛋白质组数据。它还揭示了各种黏蛋白乳杆菌菌株中常见和独特的生态位适应基因。本研究旨在获得基因组信息，揭示黏蛋白乳杆菌 LM1 益生菌作用的可能机制，并更好地了解黏蛋白乳杆菌属的性质。
