硒代-β-乳球蛋白对 S180 荷瘤小鼠的抗肿瘤和免疫调节作用。
Antitumor and Immunoregulatory Activities of Seleno-β-Lactoglobulin on S180 Tumor-Bearing Mice.
机构信息
Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
出版信息
Molecules. 2017 Dec 28;23(1):46. doi: 10.3390/molecules23010046.
Degeneration of immune organs like thymus and spleen has been discovered in tumor-bearing mice; which increases the difficulties on oncotherapy. More effective drugs which target the protection of immune organs are expected to be researched. In this study; we aim to analyze the antitumor and immunoregulatory activities of seleno-β-lactoglobulin (Se-β-lg) on S180 tumor-bearing mice. Results indicated that Se-β-lg exhibited a remarkable inhibitory effect on S180 solid tumors with the inhibition rate of 48.38%; and protected the thymuses and spleens of S180-bearing mice. In addition, Se-β-lg could also balance the proportions of CD4⁺ and CD8⁺ T cells in spleens; thymuses and peripheral bloods; and improve Levels of IL-2; IFN-γ; TNF-α in mice serums. β-lg showed weaker bioactivities while SeO₂ showed stronger toxicity on mice. Therefore our results demonstrated that Se-β-lg possessed stronger antitumor and immunoregulatory activities with lower side effects and had the potential to be a novel immunopotentiator and antitumor agent.
在荷瘤小鼠中发现免疫器官（如胸腺和脾脏）退化，这增加了肿瘤治疗的难度。人们期望研究出更有效的针对免疫器官保护的药物。本研究旨在分析硒-β-乳球蛋白（Se-β-lg）对 S180 荷瘤小鼠的抗肿瘤和免疫调节作用。结果表明，Se-β-lg 对 S180 实体瘤表现出显著的抑制作用，抑制率为 48.38%，并能保护 S180 荷瘤小鼠的胸腺和脾脏。此外，Se-β-lg 还可以平衡脾脏、胸腺和外周血中 CD4⁺和 CD8⁺T 细胞的比例，并提高小鼠血清中 IL-2、IFN-γ和 TNF-α的水平。β-lg 的生物活性较弱，而 SeO₂ 对小鼠的毒性较强。因此，我们的结果表明，Se-β-lg 具有更强的抗肿瘤和免疫调节活性，副作用更低，有可能成为一种新型的免疫增强剂和抗肿瘤药物。
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