Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Molecules. 2017 Dec 28;23(1):46. doi: 10.3390/molecules23010046.
Degeneration of immune organs like thymus and spleen has been discovered in tumor-bearing mice; which increases the difficulties on oncotherapy. More effective drugs which target the protection of immune organs are expected to be researched. In this study; we aim to analyze the antitumor and immunoregulatory activities of seleno-β-lactoglobulin (Se-β-lg) on S180 tumor-bearing mice. Results indicated that Se-β-lg exhibited a remarkable inhibitory effect on S180 solid tumors with the inhibition rate of 48.38%; and protected the thymuses and spleens of S180-bearing mice. In addition, Se-β-lg could also balance the proportions of CD4⁺ and CD8⁺ T cells in spleens; thymuses and peripheral bloods; and improve Levels of IL-2; IFN-γ; TNF-α in mice serums. β-lg showed weaker bioactivities while SeO₂ showed stronger toxicity on mice. Therefore our results demonstrated that Se-β-lg possessed stronger antitumor and immunoregulatory activities with lower side effects and had the potential to be a novel immunopotentiator and antitumor agent.
在荷瘤小鼠中发现免疫器官（如胸腺和脾脏）退化，这增加了肿瘤治疗的难度。人们期望研究出更有效的针对免疫器官保护的药物。本研究旨在分析硒-β-乳球蛋白（Se-β-lg）对 S180 荷瘤小鼠的抗肿瘤和免疫调节作用。结果表明，Se-β-lg 对 S180 实体瘤表现出显著的抑制作用，抑制率为 48.38%，并能保护 S180 荷瘤小鼠的胸腺和脾脏。此外，Se-β-lg 还可以平衡脾脏、胸腺和外周血中 CD4⁺和 CD8⁺T 细胞的比例，并提高小鼠血清中 IL-2、IFN-γ和 TNF-α的水平。β-lg 的生物活性较弱，而 SeO₂ 对小鼠的毒性较强。因此，我们的结果表明，Se-β-lg 具有更强的抗肿瘤和免疫调节活性，副作用更低，有可能成为一种新型的免疫增强剂和抗肿瘤药物。
