CONTEXT AND AIM

Probiotics have been documented with various pleotropic effects other than improving general gut health, but the potential benefits of strain-specific on wound healing are unknown. Hence, the objective of the study is to evaluate and compare the wound healing property of and on various wound models in male Wistar rats.

SUBJECTS AND METHODS

Excision wound, resutured incision wound, and dead space wounds were inflicted under light thiopentone anesthesia in male Wistar rats ( = 6, in each group). The rats received one of the orally as per their weight for a period of 10 days in resutured incision (assessed by wound breaking strength) and dead space wounds (granuloma dry weight, histopathology of granulation tissue, and biochemical hydroxyproline estimation), whereas in excision wounds, treatment was monitored by planimetry. Data were expressed as mean ± standard error of mean and analyzed by ANOVA followed by Tukey's multiple test. < 0.05 was considered as statistically significant.

RESULTS

showed a significant difference ( < 0.05) in all the three models, namely, enhanced wound contraction and decreased days for complete epithelization in excision wound; increased breaking strength in resutured incision wound; increased granuloma dry weight and cellular infiltration in granulation tissue with marked increase in collagen content indicating wound healing.

CONCLUSIONS

The study suggests that the wound healing activity of if could be extrapolated to clinical situations may decrease dosage and duration of treatment and can be a potential adjuvant to reduce hospitalization with efficient recovery after injury and sustained good health.