Department of Surgery, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Department of Colorectal Surgery, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Nutrients. 2023 Jul 6;15(13):3055. doi: 10.3390/nu15133055.
Wound healing is a multi-factorial response to tissue injury, aiming to restore tissue continuity. Numerous recent experimental and clinical studies clearly indicate that probiotics are applied topically to promote the wound-healing process. However, the precise mechanism by which they contribute to healing is not yet clear. Each strain appears to exert a distinctive, even multi-factorial action on different phases of the healing process. Given that a multi-probiotic formula exerts better results than a single strain, the pharmaceutical industry has embarked on a race for the production of a formulation containing a combination of probiotics capable of playing a role in all the phases of the healing process. Hence, the object of this review is to describe what is known to date of the distinctive mechanisms of each of the most studied probiotic strains in order to further facilitate research toward the development of combinations of strains and doses, covering the whole spectrum of healing. Eleven probiotic species have been analyzed, the only criterion of inclusion being a minimum of two published research articles.
伤口愈合是一种针对组织损伤的多因素反应，旨在恢复组织连续性。最近大量的实验和临床研究清楚地表明，益生菌可局部应用以促进伤口愈合过程。然而，它们对愈合的贡献的确切机制尚不清楚。每种菌株似乎对愈合过程的不同阶段都有独特的、甚至是多因素的作用。鉴于多益生菌配方比单一菌株能产生更好的效果，制药行业已经开始竞相生产一种含有多种益生菌的配方，这些益生菌能够在愈合过程的所有阶段发挥作用。因此，本综述的目的是描述迄今为止对研究最广泛的每种益生菌菌株的独特作用机制的了解，以便进一步促进针对菌株和剂量组合的研究，涵盖愈合的整个范围。分析了 11 种益生菌，入选的唯一标准是至少有两篇已发表的研究文章。
