Herrlinger Kelli A, Nieman Kristin M, Sanoshy Kristen D, Fonseca Brenda A, Lasrado Joanne A, Schild Arianne L, Maki Kevin C, Wesnes Keith A, Ceddia Michael A
1 Kemin Foods, LC , Des Moines, IA.
2 Biofortis Research Services/Mérieux NutriSciences , Addison, IL.
J Altern Complement Med. 2018 Jan;24(1):37-47. doi: 10.1089/acm.2016.0379. Epub 2018 Jan 9.
The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood in individuals with age-associated memory impairment (AAMI).
Subjects with AAMI (N = 90; 67% female; age = 59.4 ± 0.6 years) were randomly assigned (n = 30/group) to consume 900, 600, or 0 mg/day (two capsules, once daily) spearmint extract for 90 days, in this double-blind, placebo-controlled trial. Assessments were completed for cognition (days 0, 45, and 90), sleep (days 0 and 90), and mood (days 0 and 90) by using the Cognitive Drug Research (CDR) System, Leeds Sleep Evaluation Questionnaire (LSEQ), and Profile of Mood States (POMS), respectively.
Quality of working memory and spatial working memory accuracy improved after supplementation with 900 mg/day spearmint extract by 15% (p = 0.0469) and 9% (p = 0.0456), respectively, versus placebo. Subjects consuming 900 mg/day spearmint extract reported improvement in their ability to fall asleep, relative to subjects consuming placebo (p = 0.0046). Overall treatment effects were evident for vigor-activity (p = 0.0399), total mood disturbance (p = 0.0374), and alertness and behavior following wakefulness (p = 0.0415), with trends observed for improvements after spearmint supplementation relative to placebo.
These results suggest that the distinct spearmint extract may be a beneficial nutritional intervention for cognitive health in older subjects with AAMI.
本研究旨在调查补充富含包括迷迭香酸在内的多酚的留兰香（薄荷属辣薄荷）提取物，对患有年龄相关性记忆障碍（AAMI）的个体的认知表现、睡眠和情绪的影响。
在这项双盲、安慰剂对照试验中，患有AAMI的受试者（N = 90；67%为女性；年龄 = 59.4 ± 0.6岁）被随机分配（每组n = 30），每天服用900、600或0毫克（两粒胶囊，每日一次）留兰香提取物，持续9天。分别使用认知药物研究（CDR）系统、利兹睡眠评估问卷（LSEQ）和情绪状态剖面图（POMS）对认知（第0、45和90天）、睡眠（第0和90天）和情绪（第0和90天）进行评估。
与安慰剂相比，每天补充900毫克留兰香提取物后，工作记忆质量和空间工作记忆准确性分别提高了15%（p = 0.0469）和9%（p = 0.0456）。与服用安慰剂的受试者相比，每天服用900毫克留兰香提取物的受试者报告入睡能力有所改善（p = 0.0046）。活力活动（p = 0.0399）、总情绪紊乱（p = 0.0374）以及清醒后的警觉性和行为（p = 0.0415）的总体治疗效果明显，与安慰剂相比，留兰香补充后有改善趋势。
这些结果表明，这种独特的留兰香提取物可能是对患有AAMI的老年受试者认知健康有益的营养干预措施。
