Lekskulchai Veeravan
Department of Pathology, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.
Med Sci Monit Basic Res. 2018 Jan 12;24:10-15. doi: 10.12659/msmbr.907751.
BACKGROUND Since measured low density lipoprotein-cholesterol (LDL-C) has been available in clinical laboratories, there have been concern about the disagreement between measured and calculated LDL-C and the factors causing their disagreement. MATERIAL AND METHODS Serum lipid concentrations were collected from 1,339 medical records of patients admitted to hospital between 2013 and 2015. They were grouped by their total cholesterol (TC), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C) concentrations and the agreement between measured and calculated LDL-C was statistically analyzed. RESULTS A strong relationship was found between measured and calculated LDL-C. Significantly disagreements between measured and calculated LDL-C were found in all groups in 2013 and 2014 when lipids were analyzed by Cobas C501. Disagreements found in groups of low TG and low HDL-C concentrations in 2015 were when lipids were analyzed by Abbott Architect ci8200. In groups of calculated LDL-C <1.81 mmol/L, around 80% had the measured LDL-C >1.81 mmol/L. Among various atherogenic indices, non-HDL-C showed the strongest relationship with LDL-C, while TC to HDL-C ratio showed the strongest agreement with the LDL-C. CONCLUSIONS The disagreement between measured and calculated LDL-C in a clinical laboratory seemed to depend on the analytical system used, and was probably associated with individual laboratory variations.
背景 自从临床实验室能够检测低密度脂蛋白胆固醇（LDL-C）以来，人们一直关注检测的LDL-C与计算的LDL-C之间的差异以及导致这种差异的因素。材料与方法 收集了2013年至2015年期间住院患者的1339份病历中的血脂浓度。根据总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）浓度对患者进行分组，并对检测的LDL-C与计算的LDL-C之间的一致性进行统计学分析。结果 检测的LDL-C与计算的LDL-C之间存在很强的相关性。2013年和2014年，当使用Cobas C501分析血脂时，所有组中检测的LDL-C与计算的LDL-C之间均存在显著差异。2015年，当使用雅培Architect ci8200分析血脂时，在低TG和低HDL-C浓度组中发现了差异。在计算的LDL-C<1.81 mmol/L的组中，约80%的患者检测的LDL-C>1.81 mmol/L。在各种致动脉粥样硬化指数中，非HDL-C与LDL-C的相关性最强，而TC与HDL-C的比值与LDL-C的一致性最强。结论 临床实验室中检测的LDL-C与计算的LDL-C之间的差异似乎取决于所使用的分析系统，并且可能与各个实验室的差异有关。
