He Yunjie, Yu Dandan, Zhu Lingping, Zhong Shanliang, Zhao Jianhua, Tang Jinhai
The First Clinical School of Nanjing Medical University, Nanjing 210029, P.R. China.
Center of Clinical Laboratory, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing 210009, P.R. China.
J Cancer. 2018 Jan 1;9(2):375-388. doi: 10.7150/jca.21044. eCollection 2018.
MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are reported to play important roles in tumorigenesis and progression of various cancers. Among them, miR-149 was confirmed to be aberrantly regulated in various tumors. In this review, we provide a complex overview of miR-149, particularly summarize the critical roles of it in cancers and expect to lay the foundation for future works on this important microRNA.
微小RNA（miRNA）是一类小的非编码RNA，它们通过与靶mRNA的3'非翻译区（3'-UTR）结合来调控转录后基因表达。据报道，它们在各种癌症的发生和发展中发挥重要作用。其中，miR-149在各种肿瘤中被证实存在异常调控。在本综述中，我们对miR-149进行了全面概述，特别总结了其在癌症中的关键作用，期望为今后针对这一重要微小RNA的研究奠定基础。
