Yi Qian, Xie Wei, Sun Wei, Sun Weichao, Liao Yi
The Central Laboratory, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong 518035, P.R. China.
Department of Physiology, School of Basic Medical Science, Southwest Medical University, Luzhou, Sichuan province 646099, P.R. China.
J Cancer. 2022 Jan 1;13(1):313-324. doi: 10.7150/jca.64846. eCollection 2022.
MicroRNAs (miRNAs) are small noncoding RNAs that commonly have 18-22 nucleotides and play important roles in the regulation of gene expression via directly binding to the 3'-UTR of target mRNAs. Approximately 50% of human genes are regulated by miRNAs and they are involved in many human diseases, including various types of cancers. Recently, microRNA-383 (miR-383) has been identified as being aberrantly expressed in multiple cancers, such as malignant melanoma, colorectal cancer, hepatocellular cancer, and glioma. Increasing evidence suggests that miR-383 participates in tumorigenic events including proliferation, apoptosis, invasion, and metastasis as well as drug resistance. Although downstream targets including and are illustrated to be regulated by miR-383, its roles in carcinogenesis are still ambiguous and the underlying mechanisms are still unclear. Herein, we review the latest studies on miR-383 and summarize its functions in human cancers and other diseases. The goal of this review is to provide new strategies for targeted therapy and further investigations.
微小RNA（miRNA）是一类小的非编码RNA，通常含有18 - 22个核苷酸，通过直接结合靶mRNA的3'-UTR在基因表达调控中发挥重要作用。大约50%的人类基因受miRNA调控，它们参与许多人类疾病，包括各种类型的癌症。最近，微小RNA - 383（miR - 383）已被确定在多种癌症中异常表达，如恶性黑色素瘤、结直肠癌、肝细胞癌和神经胶质瘤。越来越多的证据表明，miR - 383参与肿瘤发生事件，包括增殖、凋亡、侵袭和转移以及耐药性。尽管已阐明包括[具体基因1]和[具体基因2]在内的下游靶标受miR - 383调控，但其在致癌作用中的作用仍不明确，潜在机制也仍不清楚。在此，我们综述了关于miR - 383的最新研究，并总结了其在人类癌症和其他疾病中的功能。本综述的目的是为靶向治疗和进一步研究提供新策略。
