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昆明白鼠中虫茶及其原茶（苦丁茶）多酚抗氧化作用的比较。

Comparison of Antioxidative Effects of Insect Tea and Its Raw Tea (Kuding Tea) Polyphenols in Kunming Mice.

机构信息

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.

Chongqing Engineering Research Center of Functional Food, Chongqing University of Education, Chongqing 400067, China.

出版信息

Molecules. 2018 Jan 19;23(1):204. doi: 10.3390/molecules23010204.

DOI:10.3390/molecules23010204
PMID:29351230
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6017035/
Abstract

Kudingcha is a traditional Chinese tea, and insect tea is a special drink produced by the metabolism of insect larvae using the raw Kuding tea. Insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) are high-purity polyphenols extracted by centrifuge precipitation. The present study was designed to compare the antioxidative effects of insect tea polyphenols (ITP) and its raw tea (Kuding tea) polyphenols (KTP) on d-galactose-induced oxidation in Kunming (KM) mice. KM mice were treated with ITP (200 mg/kg) and KTP (200 mg/kg) by gavage, and vitamin C (VC, 200 mg/kg) was also used as a positive control by gavage. After determination in serum, liver and spleen, ITP-treated mice showed higher superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione (GSH) activities and lower nitric oxide (NO), malonaldehyde (MDA) activities than VC-treated mice, KTP-treated mice and untreated oxidation mice (control group). By H&E section observation, the mice induced by d-galactose-induced oxidation showed more changes than normal mice, and oxidative damage appeared in liver and spleen tissues; ITP, VC and KTP improved oxidative damage of liver and spleen tissues, and the effects of ITP were better than VC and KTP. Using quantitative polymerase chain reaction (qPCR) and western blot experiments, it was observed that ITP could increase the mRNA and protein expression of neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), manganese superoxide dismutase (Mn-SOD), cupro/zinc superoxide dismutase (Cu/Zn-SOD), catalase (CAT), heme oxygenase-1 (HO-1), nuclear factor erythroid 2 related factor 2 (Nrf2), gamma glutamylcysteine synthetase (γ-GCS), and NAD(P)H:quinone oxidoreductase 1 (NQO1) and reduce inducible nitric oxide synthase (iNOS) expression in liver and spleen tissues compared to the control group. These effects were stronger than for VC and KTP. Both ITP and KTP had good antioxidative effects, and after the transformation of insects, the effects of ITP were better than that of KTP and even better than VC. Thus, ITP can be used as an antioxidant and anti-ageing functional food.

摘要

苦丁茶是一种传统的中国茶，而虫茶是一种由昆虫幼虫利用原苦丁茶代谢产生的特殊饮品。虫茶多酚（ITP）及其原茶（苦丁茶）多酚（KTP）是通过离心沉淀提取的高纯度多酚。本研究旨在比较虫茶多酚（ITP）及其原茶（苦丁茶）多酚（KTP）对 D-半乳糖诱导的昆明（KM）小鼠氧化的抗氧化作用。通过灌胃给予 ITP（200mg/kg）和 KTP（200mg/kg），并用维生素 C（VC，200mg/kg）作为阳性对照进行灌胃，测定血清、肝和脾中 IT 的含量。与 VC 处理组、KTP 处理组和未处理氧化组（对照组）相比，ITP 处理组小鼠的超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和谷胱甘肽（GSH）活性更高，一氧化氮（NO）、丙二醛（MDA）活性更低。通过 H&E 切片观察，D-半乳糖诱导氧化的小鼠比正常小鼠表现出更多的变化，肝和脾组织出现氧化损伤；ITP、VC 和 KTP 改善肝和脾组织的氧化损伤，ITP 的作用优于 VC 和 KTP。通过定量聚合酶链反应（qPCR）和 Western blot 实验观察到，ITP 可增加神经元型一氧化氮合酶（nNOS）、内皮型一氧化氮合酶（eNOS）、锰超氧化物歧化酶（Mn-SOD）、铜/锌超氧化物歧化酶（Cu/Zn-SOD）、过氧化氢酶（CAT）、血红素加氧酶-1（HO-1）、核因子红细胞 2 相关因子 2（Nrf2）、γ-谷氨酰半胱氨酸合成酶（γ-GCS）和 NAD（P）H：醌氧化还原酶 1（NQO1）的 mRNA 和蛋白表达，并降低肝和脾组织中诱导型一氧化氮合酶（iNOS）的表达，与对照组相比，这些作用比 VC 和 KTP 更强。ITP 和 KTP 均具有良好的抗氧化作用，且经过昆虫转化后，ITP 的效果优于 KTP，甚至优于 VC。因此，ITP 可作为一种抗氧化和抗衰老的功能性食品。

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