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锦鲤及锦鲤×红鲤对锦鲤疱疹病毒（KHV）的免疫反应

Immune Response to Koi Herpesvirus (KHV) of Koi and Koi × Red Common Carp ().

作者信息

Hwang Ju-Ae, Kim Jung Eun, Kim Hyeong-Su, Lee Jeong-Ho

机构信息

Inland Aquaculture Research Center, National Institute of Fisheries Science (NIFS), Changwon 51688, Korea.

出版信息

Dev Reprod. 2017 Dec;21(4):361-370. doi: 10.12717/DR.2017.21.4.361. Epub 2017 Dec 31.

DOI:10.12717/DR.2017.21.4.361
PMID:29354782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5769130/
Abstract

Koi herpesvirus (KHV), also known as Cyprinid herpes virus 3 (Cyprinid 3) is lethal disease in common carp and koi (). Two different groups (KK and RK) were infected KHV by intraperitoneal injection. Fish for gene expression analysis were sampled at 0 h, 12 h, 24 h, 48 h and 72 h post infection (p.i). The results showed that two immune related gene, Interferons (INFs) ɑβ and Interleukin (IL)-12 p35 induced a high response in RK. The IL-12 p35 cytokine and Toll-like receptor (TLR) 9 were significantly high expressed on 48 h post infection (p.i) in RK as compared to the KK. The histopatological examination reveals focal necrosis in liver and infiltrate of lymphocytes in spleen of KK as compared to the RK. In immunohistochemistry analysis, the KHV protein high expressed in the infected kidney cell and slenocyte of KK. Therefore, the expression of IL-12 p35, IFN ɑβ and TLR 9 may provide a potentially genes related with KHV resistance in Koi and red common carp × koi.

摘要

锦鲤疱疹病毒（KHV），也被称为鲤疱疹病毒3型（Cyprinid 3），是鲤鱼和锦鲤的致死性疾病。通过腹腔注射将两组不同的鱼（KK和RK）感染KHV。用于基因表达分析的鱼在感染后0小时、12小时、24小时、48小时和72小时进行采样。结果表明，两个免疫相关基因，干扰素（INFs）αβ和白细胞介素（IL）-12 p35在RK中引发了高反应。与KK相比，IL-12 p35细胞因子和Toll样受体（TLR）9在RK感染后48小时显著高表达。组织病理学检查显示，与RK相比，KK的肝脏出现局灶性坏死，脾脏有淋巴细胞浸润。在免疫组织化学分析中，KHV蛋白在KK感染的肾细胞和脾细胞中高表达。因此，IL-12 p35、IFNαβ和TLR 9的表达可能为锦鲤和红鲤×锦鲤中与KHV抗性相关的潜在基因提供依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c08/5769130/9dbcf2c84d6e/dr-21-4-361-g7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c08/5769130/8ff4a42e4656/dr-21-4-361-g1.jpg
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