[长链非编码RNA在非小细胞肺癌中的研究进展]
[Progress of Long Non-coding RNA in Non-small Cell Lung Cancer].
作者信息
Zhang Yachen, Liang Di, Jin Jing, Liu Congmin, He Yutong
机构信息
The Fourth Hospital of Heibei Medical University, Cancer Institute, Shijiazhuang 050011, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2018 Jan 20;21(1):43-49. doi: 10.3779/j.issn.1009-3419.2018.01.06.
Abstract
Lung cancer is one of the most important malignant tumors in the world. The morbidity and mortality rank the first in all kinds of cancer. Long non-coding RNA (lncRNA) is at least 200 nt long and has no protein coding capacity. It plays an important role in the epigenetic regulation, cell cycle regulation, the regulation of cell differentiation, and many other life activities. The studies indicate that dysregulation of lncRNAs in non-small cell lung cancer (NSCLC) tissue and blood circulation is associated with the occurrence and development of cancer. The lncRNAs play an significant role in proliferation, differentiation, migration and apoptosis of the tumor cells. Explore the potential mechanism between lncRNAs and NSCLC is beneficial for the early diagnosis, target therpy and improve prognosis. Therefore, the study aims to demonstrate the latest studies on the lncRNAs related to occurence, diagnosis, therpy and prognosis of NSCLC. It can help to deeply understanding of lncRNA, and provide new ideas for the prevention of NSCLC.
摘要
肺癌是世界上最重要的恶性肿瘤之一。其发病率和死亡率在各类癌症中位居首位。长链非编码RNA（lncRNA）长度至少为200个核苷酸，且无蛋白质编码能力。它在表观遗传调控、细胞周期调控、细胞分化调控以及许多其他生命活动中发挥着重要作用。研究表明，非小细胞肺癌（NSCLC）组织和血液循环中lncRNAs的失调与癌症的发生和发展相关。lncRNAs在肿瘤细胞的增殖、分化、迁移和凋亡中发挥着重要作用。探索lncRNAs与NSCLC之间的潜在机制有利于早期诊断、靶向治疗并改善预后。因此，本研究旨在阐述与NSCLC发生、诊断、治疗和预后相关的lncRNAs的最新研究。这有助于深入了解lncRNA，并为NSCLC的预防提供新思路。
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