Stone R A, Glembotski C C
Biochem Biophys Res Commun. 1986 Jan 29;134(2):1022-8. doi: 10.1016/s0006-291x(86)80523-x.
Acid extracts of rat anterior uvea and retina contain immunoactive atrial natriuretic peptide. Gel filtration chromatography demonstrates that the major forms of the uveal and retinal material have approximate molecular weights of 2400 and 1750 daltons respectively, similar in size to the hypothalamic form of the peptide but clearly distinguishable from the larger, cardiac form. When further analyzed by RP-HPLC, the immunoactive material from both ocular tissues elutes at a position similar to atrial natriuretic peptide-28, again distinguishing the ocular and cardiac forms of immunoactive material. These results suggest potential roles for atrial natriuretic peptide both in ocular vegetative physiology and in retinal function.
大鼠前葡萄膜和视网膜的酸性提取物含有免疫活性心房利钠肽。凝胶过滤色谱法表明，葡萄膜和视网膜物质的主要形式的分子量分别约为2400和1750道尔顿，其大小与该肽的下丘脑形式相似，但与较大的心脏形式明显不同。当通过反相高效液相色谱进一步分析时，来自两种眼组织的免疫活性物质在与心房利钠肽-28相似的位置洗脱，再次区分了眼和心脏形式的免疫活性物质。这些结果表明心房利钠肽在眼植物生理学和视网膜功能中都具有潜在作用。
