Song Chang Hun, Bae Hong Jin, Ham Young Rok, Na Ki Ryang, Lee Kang Wook, Choi Dae Eun
Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
Electrolyte Blood Press. 2017 Dec;15(2):47-51. doi: 10.5049/EBP.2017.15.2.47. Epub 2017 Dec 31.
Ethylene glycol is a widely used and readily available substance. Ethylene glycol ingestion does not cause direct toxicity; however, its metabolites are highly toxic and can be fatal even in trace amounts. Poisoning is best diagnosed through inquiry, but as an impaired state of consciousness is observed in most cases, poisoning must be suspected when a significantly elevated osmolar gap or high anion gap metabolic acidosis is found in blood tests. Hemodialysis and alcohol dehydrogenase inhibitors such as ethanol and fomepizole are a part of the basic treatment, and timely diagnosis and treatment are crucial because any delays can lead to death. However, there are few reported cases in Korea, and no report on the use of fomepizole. Herein, we report a case of acute renal failure caused by ethylene glycol poisoning that was treated with fomepizole and hemodialysis and present a literature review.
乙二醇是一种广泛使用且易于获取的物质。摄入乙二醇本身不会直接产生毒性；然而，其代谢产物具有高度毒性，即使微量也可能致命。中毒最好通过询问来诊断，但由于大多数病例会出现意识障碍，所以当血液检查发现渗透压间隙显著升高或高阴离子间隙代谢性酸中毒时，必须怀疑中毒。血液透析以及乙醇和甲吡唑等酒精脱氢酶抑制剂是基本治疗的一部分，及时诊断和治疗至关重要，因为任何延误都可能导致死亡。然而，韩国报道的病例很少，且没有关于使用甲吡唑的报告。在此，我们报告一例用甲吡唑和血液透析治疗的乙二醇中毒所致急性肾衰竭病例，并进行文献综述。
