Dickgiesser N, in der Stroth S, Wundt W
Infection. 1986 Mar-Apr;14(2):82-5. doi: 10.1007/BF01644449.
Studies on the Synergism of Ciprofloxacin with beta-Lactam Antibiotics, Gentamicin, Minocycline and Pipemidic Acid. Using Escherichia coli, Klebsiella pneumoniae/Klebsiella oxytoca, Pseudomonas aeruginosa and Staphylococcus aureus strains, we examined a possible influence of pipemidic acid, minocycline, gentamicin, cefazolin, mezlocillin and ampicillin on the antibiotic activity of ciprofloxacin. We found in all bacterial species synergistic influence by pipemidic acid. When ciprofloxacin was combined with gentamicin, synergism was observed in E. coli and in K. pneumoniae/oxytoca, additive effects in P. aeruginosa and S. aureus. In combination with minocycline we demonstrated synergism in S. aureus only. In all other bacterial species and antibiotic combinations we found neither synergism nor antagonism.
环丙沙星与β-内酰胺类抗生素、庆大霉素、米诺环素和吡哌酸协同作用的研究。我们使用大肠杆菌、肺炎克雷伯菌/产酸克雷伯菌、铜绿假单胞菌和金黄色葡萄球菌菌株，研究了吡哌酸、米诺环素、庆大霉素、头孢唑林、美洛西林和氨苄西林对环丙沙星抗菌活性的可能影响。我们发现在所有细菌种类中，吡哌酸都有协同作用。当环丙沙星与庆大霉素联合使用时，在大肠杆菌和肺炎克雷伯菌/产酸克雷伯菌中观察到协同作用，在铜绿假单胞菌和金黄色葡萄球菌中观察到相加作用。与米诺环素联合使用时，仅在金黄色葡萄球菌中表现出协同作用。在所有其他细菌种类和抗生素组合中，我们既未发现协同作用也未发现拮抗作用。
