Hanssen Henner, Minghetti Alice, Faude Oliver, Schmidt-Trucksäss Arno, Zahner Lukas, Beck Johannes, Donath Lars
Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Klinikum Sonnhalde, Psychiatrie und Psychotherapie, Riehen, Switzerland.
Front Psychiatry. 2018 Jan 22;8:311. doi: 10.3389/fpsyt.2017.00311. eCollection 2017.
Psychiatric disorders are associated with a higher prevalence of cardiovascular disease and mortality. Regular exercise has been shown to reduce depressive symptoms and improve arterial stiffness as a biomarker of cardiovascular risk. We aimed to investigate the effects of different exercise modalities on depression severity index and arterial stiffness in patients suffering from unipolar depression.
34 patients suffering from unipolar depression [female: 25, male: 9, age: 37.8, Beck-Depression-Inventory-II (BDI-II) score: 31.0] were enrolled in this two-armed randomized controlled trial. Central hemodynamics, augmentation index at heart rate 75/min (AIx@75) and aortic pulse wave velocity (PWV) were obtained by an oscillometric monitoring device. Maximal bicycle ergometer exercise testing yielded maximal fitness parameters. Patients were assigned to either high-intensity low volume (HILV) or moderate continuous aerobic training (MCT). Both intervention groups trained three times a week during a 4-week intervention period. BDI-II were filled out by the patients before and after the intervention period.
We found moderate interaction effects on depression severity reduction [Formula: see text]. HILV showed a 85% beneficial effect in lowering BDI-II scores compared to MCT (HILV: pre: 28.8 (9.5), post: 15.5 (8.5), SMD = 1.48), MCT: (pre: 33.8 (8.5), post: 22.6 (7.5), SMD = 1.40). Reduction of AIx@75 was more pronounced after MCT (SMD = 0.61) compared to HILV (SMD = 0.08), showing 37% possibly beneficial effects of MCT over HILV. PWV remained unchanged in both training groups.
Both training regimes showed large effects on the reduction of depressive symptoms. While HILV was more effective in lowering depression severity, MCT was more effective in additionally lowering peripheral arterial stiffness. Exercise should be considered an important strategy for preventive as well as rehabilitative treatment in depression.
精神障碍与心血管疾病的较高患病率和死亡率相关。规律运动已被证明可减轻抑郁症状，并改善作为心血管风险生物标志物的动脉僵硬度。我们旨在研究不同运动方式对单相抑郁症患者抑郁严重程度指数和动脉僵硬度的影响。
34例单相抑郁症患者[女性：25例，男性：9例，年龄：37.8岁，贝克抑郁量表第二版（BDI-II）评分：31.0]纳入了这项双臂随机对照试验。通过示波监测设备获得中心血流动力学、心率75次/分钟时的增强指数（AIx@75）和主动脉脉搏波速度（PWV）。最大运动自行车测力计测试得出最大体能参数。患者被分配至高强度低容量（HILV）或中等强度持续有氧运动训练（MCT）组。两个干预组在为期4周的干预期内每周训练3次。患者在干预期前后填写BDI-II。
我们发现对抑郁严重程度降低有中度交互作用[公式：见正文]。与MCT相比，HILV在降低BDI-II评分方面显示出85%的有益效果（HILV：干预前：28.8（9.5），干预后：15.5（8.5），标准化均数差（SMD）=1.48），MCT：（干预前：33.8（8.5），干预后：22.6（7.5），SMD=1.40）。与HILV（SMD=0.08）相比，MCT后AIx@75的降低更明显（SMD=0.61），表明MCT比HILV有37%的可能有益效果。两个训练组的PWV均保持不变。
两种训练方案对减轻抑郁症状均有显著效果。虽然HILV在降低抑郁严重程度方面更有效，但MCT在额外降低外周动脉僵硬度方面更有效。运动应被视为抑郁症预防和康复治疗的重要策略。
