七种喹诺酮类药物对100株艰难梭菌临床分离株的体外活性比较
Comparative in vitro activity of seven quinolones against 100 clinical isolates of Clostridium difficile.
作者信息
Delmee M, Avesani V
出版信息
Antimicrob Agents Chemother. 1986 Feb;29(2):374-5. doi: 10.1128/AAC.29.2.374.
Abstract
The in vitro activity of seven quinolone derivatives against 100 clinical isolates of Clostridium difficile was determined. CI934 was the most active, inhibiting 90% of the strains at 4 micrograms/ml and 100% at 8 micrograms/ml. Ofloxacin and ciprofloxacin had moderate activity (16 and 32 micrograms/ml) whereas enoxacin, pefloxacin, norfloxacin, and nalidixic acid had poor activity (128 micrograms/ml).
摘要
测定了七种喹诺酮衍生物对100株艰难梭菌临床分离株的体外活性。CI934活性最强，在4微克/毫升时可抑制90%的菌株，在8微克/毫升时可抑制100%的菌株。氧氟沙星和环丙沙星活性中等（分别为16和32微克/毫升），而依诺沙星、培氟沙星、诺氟沙星和萘啶酸活性较差（128微克/毫升）。
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