调节性 T 细胞在病毒感染的免疫发病机制和免疫治疗中的作用。
The role of regulatory T cells in immunopathogenesis and immunotherapy of viral infections.
机构信息
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol I.R., Iran.
出版信息
Infect Genet Evol. 2018 Apr;59:32-37. doi: 10.1016/j.meegid.2018.01.015. Epub 2018 Feb 4.
Two hepatotropic viruses hepatitis C virus (HCV) and hepatitis B virus (HBV) have been considered as the main cause of chronic viral infections. In addition, human immunodeficiency virus (HIV) attacks the immune system by eradication of some white blood cell (T-helper cell). The role of Tregs in HCV, HBV and HIV infections ranges from suppressing antiviral T cell responses to protecting tissues as liver and immune cells from immune mediated injury. In this review, we discuss the influence of regulatory T cells in immunopathology of specific viral infections including HCV, HBV and HIV by focusing on targeting Tregs as novel approach in vaccinology against viral infections.
两种嗜肝病毒——丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）已被认为是慢性病毒感染的主要原因。此外，人类免疫缺陷病毒（HIV）通过清除某些白细胞（辅助性 T 细胞）来攻击免疫系统。调节性 T 细胞（Tregs）在 HCV、HBV 和 HIV 感染中的作用范围从抑制抗病毒 T 细胞反应到保护肝脏和免疫细胞等组织免受免疫介导的损伤。在这篇综述中，我们通过关注靶向 Tregs 作为针对病毒感染的新型疫苗接种方法，讨论了调节性 T 细胞在 HCV、HBV 和 HIV 等特定病毒感染的免疫病理学中的影响。
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