Liang Dachao, Leung Ross Ka-Kit, Guan Wenda, Au William W
Division of Genomics and Bioinformatics, CUHK-BGI Innovation Institute of Trans-omics Hong Kong, Hong Kong SAR, China.
2State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong China.
Gut Pathog. 2018 Jan 25;10:3. doi: 10.1186/s13099-018-0230-4. eCollection 2018.
The commensal, symbiotic, and pathogenic microbial community which resides inside our body and on our skin (the human microbiome) can perturb host energy metabolism and immunity, and thus significantly influence development of a variety of human diseases. Therefore, the field has attracted unprecedented attention in the last decade. Although a large amount of data has been generated, there are still many unanswered questions and no universal agreements on how microbiome affects human health have been agreed upon. Consequently, this review was written to provide an updated overview of the rapidly expanding field, with a focus on revealing knowledge gaps and research opportunities. Specifically, the review covered animal physiology, optimal microbiome standard, health intervention by manipulating microbiome, knowledge base building by text mining, microbiota community structure and its implications in human diseases and health monitoring by analyzing microbiome in the blood. The review should enhance interest in conducting novel microbiota investigations that will further improve health and therapy.
存在于我们体内和皮肤上的共生、共生和致病微生物群落（人类微生物组）会干扰宿主能量代谢和免疫，从而显著影响多种人类疾病的发展。因此，该领域在过去十年中受到了前所未有的关注。尽管已经产生了大量数据，但仍有许多未解决的问题，并且对于微生物组如何影响人类健康尚未达成普遍共识。因此，撰写本综述是为了提供这个快速发展领域的最新概述，重点是揭示知识空白和研究机会。具体而言，该综述涵盖了动物生理学、最佳微生物组标准、通过操纵微生物组进行健康干预、通过文本挖掘建立知识库、微生物群群落结构及其在人类疾病中的意义以及通过分析血液中的微生物组进行健康监测。该综述应能增强人们对开展新型微生物群调查的兴趣，这些调查将进一步改善健康状况和治疗方法。
