• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

《通过超密集皮质图特征化的鼠大脑皮质连接组，通过独特的连接模式保持特异性》

The Mouse Cortical Connectome, Characterized by an Ultra-Dense Cortical Graph, Maintains Specificity by Distinct Connectivity Profiles.

机构信息

Université Lyon, Université Claude Bernard Lyon 1, INSERM, Stem Cell and Brain Research Institute U1208, 69500 Bron, France.

Université Lyon, Université Claude Bernard Lyon 1, INSERM, Stem Cell and Brain Research Institute U1208, 69500 Bron, France; Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences (CAS) Key Laboratory of Primate Neurobiology, CAS, Shanghai 200031, China.

出版信息

Neuron. 2018 Feb 7;97(3):698-715.e10. doi: 10.1016/j.neuron.2017.12.037.

DOI:10.1016/j.neuron.2017.12.037
PMID:29420935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5958229/
Abstract

The inter-areal wiring pattern of the mouse cerebral cortex was analyzed in relation to a refined parcellation of cortical areas. Twenty-seven retrograde tracer injections were made in 19 areas of a 47-area parcellation of the mouse neocortex. Flat mounts of the cortex and multiple histological markers enabled detailed counts of labeled neurons in individual areas. The observed log-normal distribution of connection weights to each cortical area spans 5 orders of magnitude and reveals a distinct connectivity profile for each area, analogous to that observed in macaques. The cortical network has a density of 97%, considerably higher than the 66% density reported in macaques. A weighted graph analysis reveals a similar global efficiency but weaker spatial clustering compared with that reported in macaques. The consistency, precision of the connectivity profile, density, and weighted graph analysis of the present data differ significantly from those obtained in earlier studies in the mouse.

摘要

分析了与皮层区域细分相关的小鼠大脑皮层的区域间布线模式。在小鼠新皮层的 47 个分区的 19 个分区中进行了 27 次逆行示踪剂注射。皮质的平片和多种组织学标记物使我们能够对每个区域中的标记神经元进行详细计数。观察到的连接权重的对数正态分布跨越 5 个数量级，为每个区域揭示了独特的连接模式，类似于在猕猴中观察到的模式。皮质网络的密度为 97%，明显高于猕猴报告的 66%密度。加权图分析显示，与猕猴相比，全局效率相似，但空间聚类较弱。与之前在小鼠中进行的研究相比，本研究中数据的连接模式的一致性、精度、密度和加权图分析有显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/82e47ef3746d/nihms931062f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/f0ad21fb988c/nihms931062f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/e0bb9498d9a7/nihms931062f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/2923e1a6c88a/nihms931062f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/d8411c1d987f/nihms931062f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/e155cff895b6/nihms931062f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/c2dc9ad36465/nihms931062f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/1787287a815d/nihms931062f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/82e47ef3746d/nihms931062f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/f0ad21fb988c/nihms931062f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/e0bb9498d9a7/nihms931062f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/2923e1a6c88a/nihms931062f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/d8411c1d987f/nihms931062f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/e155cff895b6/nihms931062f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/c2dc9ad36465/nihms931062f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/1787287a815d/nihms931062f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19cd/5958229/82e47ef3746d/nihms931062f8.jpg

相似文献

1
The Mouse Cortical Connectome, Characterized by an Ultra-Dense Cortical Graph, Maintains Specificity by Distinct Connectivity Profiles.《通过超密集皮质图特征化的鼠大脑皮质连接组，通过独特的连接模式保持特异性》
Neuron. 2018 Feb 7;97(3):698-715.e10. doi: 10.1016/j.neuron.2017.12.037.
2
Why data coherence and quality is critical for understanding interareal cortical networks.为什么数据一致性和质量对于理解脑区间皮质网络至关重要。
Neuroimage. 2013 Oct 15;80:37-45. doi: 10.1016/j.neuroimage.2013.04.031. Epub 2013 Apr 18.
3
Statistical Analysis of Tract-Tracing Experiments Demonstrates a Dense, Complex Cortical Network in the Mouse.示踪实验的统计分析表明小鼠存在密集、复杂的皮质网络。
PLoS Comput Biol. 2016 Sep 12;12(9):e1005104. doi: 10.1371/journal.pcbi.1005104. eCollection 2016 Sep.
4
Spatial Embedding and Wiring Cost Constrain the Functional Layout of the Cortical Network of Rodents and Primates.空间嵌入和布线成本限制了啮齿动物和灵长类动物皮质网络的功能布局。
PLoS Biol. 2016 Jul 21;14(7):e1002512. doi: 10.1371/journal.pbio.1002512. eCollection 2016 Jul.
5
Structural Attributes and Principles of the Neocortical Connectome in the Marmoset Monkey.食蟹猴新皮层连接组的结构属性和原理。
Cereb Cortex. 2021 Nov 23;32(1):15-28. doi: 10.1093/cercor/bhab191.
6
Cortical parcellation based on structural connectivity: A case for generative models.基于结构连接的皮质分割：生成模型的案例。
Neuroimage. 2018 Jun;173:592-603. doi: 10.1016/j.neuroimage.2018.01.077. Epub 2018 Jan 31.
7
Neuron density fundamentally relates to architecture and connectivity of the primate cerebral cortex.神经元密度与灵长类大脑皮层的结构和连接有着根本的关系。
Neuroimage. 2019 Apr 1;189:777-792. doi: 10.1016/j.neuroimage.2019.01.010. Epub 2019 Jan 21.
8
Non-uniformity of neocortex: areal heterogeneity of NADPH-diaphorase reactive neurons in adult macaque monkeys.新皮层的不均匀性：成年猕猴中NADPH-黄递酶反应性神经元的区域异质性。
Cereb Cortex. 2000 Feb;10(2):160-74. doi: 10.1093/cercor/10.2.160.
9
Spatial embedding of structural similarity in the cerebral cortex.大脑皮层中结构相似性的空间嵌入
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16580-5. doi: 10.1073/pnas.1414153111. Epub 2014 Nov 3.
10
Kuramoto model simulation of neural hubs and dynamic synchrony in the human cerebral connectome.人类大脑连接组中神经枢纽与动态同步的Kuramoto模型模拟
BMC Neurosci. 2015 Sep 2;16:54. doi: 10.1186/s12868-015-0193-z.

引用本文的文献

1
Enhancement of brain atlases with laminar coordinate systems: Flatmaps and barrel column annotations.利用层状坐标系增强脑图谱：平面地图和桶状柱注释。
Imaging Neurosci (Camb). 2024 Jun 28;2. doi: 10.1162/imag_a_00209. eCollection 2024.
2
Neurons throughout the brain embed robust signatures of their anatomical location into spike trains.大脑中的神经元会将其解剖位置的强大特征嵌入到尖峰序列中。
Elife. 2025 Jun 27;13:RP101506. doi: 10.7554/eLife.101506.
3
From comparative connectomics to large-scale working memory modeling in macaque and marmoset.

本文引用的文献

1
Network control principles predict neuron function in the Caenorhabditis elegans connectome.网络控制原理可预测秀丽隐杆线虫连接组中的神经元功能。
Nature. 2017 Oct 26;550(7677):519-523. doi: 10.1038/nature24056. Epub 2017 Oct 18.
2
Simultaneous intrinsic signal imaging of auditory and visual cortex reveals profound effects of acute hearing loss on visual processing.同时进行听觉和视觉皮层的内源信号成像揭示了急性听力损失对视觉处理的深远影响。
Neuroimage. 2017 Oct 1;159:459-472. doi: 10.1016/j.neuroimage.2017.07.037. Epub 2017 Jul 20.
3
A multiscale cerebral neurochemical connectome of the rat brain.
从比较连接组学到猕猴和狨猴的大规模工作记忆建模
bioRxiv. 2025 Mar 17:2025.03.17.643781. doi: 10.1101/2025.03.17.643781.
4
Interdigitating Modules for Visual Processing During Locomotion and Rest in Mouse V1.小鼠初级视觉皮层中在运动和休息期间用于视觉处理的指状模块
bioRxiv. 2025 Feb 25:2025.02.21.639505. doi: 10.1101/2025.02.21.639505.
5
Neuroanatomical Mapping of Gerbil Corticostriatal and Thalamostriatal Projections Reveals the Parafascicular Nucleus as a Relay for Vestibular Information to the Entire Striatum.沙鼠皮质纹状体和丘脑纹状体投射的神经解剖图谱揭示了束旁核作为前庭信息传递至整个纹状体的中继站。
eNeuro. 2025 Mar 14;12(3). doi: 10.1523/ENEURO.0246-24.2025. Print 2025 Mar.
6
Higher-order thalamic input to cortex selectively conveys state information.丘脑向皮层的高阶输入选择性地传递状态信息。
Cell Rep. 2025 Feb 25;44(2):115292. doi: 10.1016/j.celrep.2025.115292. Epub 2025 Feb 11.
7
A generative model of the connectome with dynamic axon growth.一个具有动态轴突生长的连接组生成模型。
Netw Neurosci. 2024 Dec 10;8(4):1192-1211. doi: 10.1162/netn_a_00397. eCollection 2024.
8
Mesoscale functional architecture in medial posterior parietal cortex.内侧后顶叶皮层的中尺度功能结构
bioRxiv. 2024 Dec 2:2023.08.27.555017. doi: 10.1101/2023.08.27.555017.
9
Multi-scale spiking network model of human cerebral cortex.人类大脑皮层的多尺度尖峰网络模型。
Cereb Cortex. 2024 Oct 3;34(10). doi: 10.1093/cercor/bhae409.
10
A Novel Directed Seed-Based Connectivity Analysis Toolbox Applied to Human and Marmoset Resting-State FMRI.一种新颖的基于种子的定向连通性分析工具箱，应用于人及狨猴静息态 fMRI。
J Neurosci. 2024 Nov 6;44(45):e0389242024. doi: 10.1523/JNEUROSCI.0389-24.2024.
大鼠脑的多尺度脑神经化学连接组
PLoS Biol. 2017 Jul 3;15(7):e2002612. doi: 10.1371/journal.pbio.2002612. eCollection 2017 Jul.
4
An extended retinotopic map of mouse cortex.小鼠皮层的扩展视网膜拓扑图谱。
Elife. 2017 Jan 6;6:e18372. doi: 10.7554/eLife.18372.
5
Small-World Brain Networks Revisited.再次探讨小世界脑网络。
Neuroscientist. 2017 Oct;23(5):499-516. doi: 10.1177/1073858416667720. Epub 2016 Sep 21.
6
Statistical Analysis of Tract-Tracing Experiments Demonstrates a Dense, Complex Cortical Network in the Mouse.示踪实验的统计分析表明小鼠存在密集、复杂的皮质网络。
PLoS Comput Biol. 2016 Sep 12;12(9):e1005104. doi: 10.1371/journal.pcbi.1005104. eCollection 2016 Sep.
7
Spatial Embedding and Wiring Cost Constrain the Functional Layout of the Cortical Network of Rodents and Primates.空间嵌入和布线成本限制了啮齿动物和灵长类动物皮质网络的功能布局。
PLoS Biol. 2016 Jul 21;14(7):e1002512. doi: 10.1371/journal.pbio.1002512. eCollection 2016 Jul.
8
Robust neuronal dynamics in premotor cortex during motor planning.运动规划期间运动前皮质中稳健的神经元动力学。
Nature. 2016 Apr 28;532(7600):459-64. doi: 10.1038/nature17643. Epub 2016 Apr 13.
9
Comparative Connectomics.比较连接组学。
Trends Cogn Sci. 2016 May;20(5):345-361. doi: 10.1016/j.tics.2016.03.001. Epub 2016 Mar 26.
10
Thalamus plays a central role in ongoing cortical functioning.丘脑在大脑皮层的持续活动中起着核心作用。
Nat Neurosci. 2016 Apr;19(4):533-41. doi: 10.1038/nn.4269.