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本文引用的文献

1
Annotation and De Novo Sequence Characterization of Extracellular β-Fructofuranosidase from Strain HKF42.菌株HKF42胞外β-呋喃果糖苷酶的注释及从头测序表征
Indian J Microbiol. 2018 Jun;58(2):227-233. doi: 10.1007/s12088-017-0704-y. Epub 2018 Jan 4.
2
Genome sequence of 9-3 provides insights into lignocellulose degradation.9-3的基因组序列为木质纤维素降解研究提供了见解。
3 Biotech. 2017 Dec;7(6):368. doi: 10.1007/s13205-017-1001-5. Epub 2017 Oct 10.
3
Sources of β-galactosidase and its applications in food industry.β-半乳糖苷酶的来源及其在食品工业中的应用。
3 Biotech. 2017 May;7(1):79. doi: 10.1007/s13205-017-0645-5. Epub 2017 May 12.
4
Draft genome sequence of Talaromyces islandicus ("Penicillium islandicum") WF-38-12, a neglected mold with significant biotechnological potential.塔宾曲霉（“岛青霉”）WF-38-12 的基因组草图，一种具有重要生物技术潜力但被忽视的霉菌。
J Biotechnol. 2015 Oct 10;211:101-2. doi: 10.1016/j.jbiotec.2015.07.004. Epub 2015 Jul 18.
5
Genome, Transcriptome, and Functional Analyses of Penicillium expansum Provide New Insights Into Secondary Metabolism and Pathogenicity.扩展青霉的基因组、转录组及功能分析为其次级代谢和致病性提供了新见解。
Mol Plant Microbe Interact. 2015 Mar;28(3):232-48. doi: 10.1094/MPMI-09-14-0261-FI.
6
Optimization of inulinase production by a newly isolated Aspergillus tubingensis CR16 using low cost substrates.利用低成本基质对新分离的串珠镰刀菌 CR16 菊粉酶生产的优化。
Carbohydr Polym. 2012 Sep 1;90(1):483-90. doi: 10.1016/j.carbpol.2012.05.068. Epub 2012 May 28.
7
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J Biosci Bioeng. 2014 Apr;117(4):443-8. doi: 10.1016/j.jbiosc.2013.09.017. Epub 2013 Oct 31.
8
Molecular modeling and docking of microbial inulinases towards perceptive enzyme-substrate interactions.微生物菊粉酶的分子建模和对接研究及其对酶-底物相互作用的感知。
Indian J Microbiol. 2012 Sep;52(3):373-80. doi: 10.1007/s12088-012-0248-0. Epub 2012 Jan 21.
9
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler.SOAPdenovo2：一种经验丰富的、内存效率高的短读长从头组装器。
Gigascience. 2012 Dec 27;1(1):18. doi: 10.1186/2047-217X-1-18.
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Genome sequence of the necrotrophic fungus Penicillium digitatum, the main postharvest pathogen of citrus.柑橘采后主要病原菌——产毒青霉的基因组序列
BMC Genomics. 2012 Nov 21;13:646. doi: 10.1186/1471-2164-13-646.

菌株HKF2的基因组序列草图，HKF2是一种具有生产益生元合成酶潜力的真菌。

Draft genome sequence of strain HKF2, a fungus with potential for production of prebiotic synthesizing enzymes.

作者信息

Gujar Vaibhav V, Fuke Priya, Khardenavis Anshuman A, Purohit Hemant J

机构信息

1CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), Nehru Marg, Nagpur, India.

2Academy of Scientific and Innovative Research (AcSIR), CSIR-NEERI, Nehru Marg, Nagpur, 440020 India.

出版信息

3 Biotech. 2018 Feb;8(2):106. doi: 10.1007/s13205-018-1132-3. Epub 2018 Feb 1.

DOI:10.1007/s13205-018-1132-3
PMID:29430367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5794679/
Abstract

In this study, we have characterized a novel set of extracellular enzymes produced by strain HKF2. A draft genome data of 31.5 Mbp was generated and annotation suggested a total of 11,243 protein-coding genes out of which 609 were CAZymes, majority of which were found to have homology with followed by and . The prominent CAZyme genes identified in the draft genome encoded for enzymes involved in the production of prebiotics such as inulo-oligosaccharides and fructo-oligosaccharides. Corresponding enzyme assay indicated that the isolate possessed the potential to produce 11.8 and 3.8 U/mL of β-fructofuranosidase and inulinase, respectively. This study highlights the significance of Effluent Treatment Plants as novel and under-explored niche for isolation of fungi having the potential for production of prebiotics synthesizing enzymes.

摘要

在本研究中，我们对菌株HKF2产生的一组新型胞外酶进行了表征。生成了一份31.5兆碱基对的基因组草图数据，注释显示共有11243个蛋白质编码基因，其中609个是碳水化合物活性酶（CAZymes），其中大部分被发现与[具体内容缺失]具有同源性，其次是[具体内容缺失]和[具体内容缺失]。在基因组草图中鉴定出的突出CAZyme基因编码参与益生元（如低聚果糖和低聚菊糖）生产的酶。相应的酶活性测定表明，该分离株分别具有产生11.8和3.8 U/mL的β-呋喃果糖苷酶和菊粉酶的潜力。本研究强调了污水处理厂作为分离具有益生元合成酶生产潜力真菌的新型且未充分探索的生态位的重要性。